Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

被引：10
作者：
Yang, Xue [1 ,2 ]
Wang, Ying [2 ]
Rovella, Valentina [1 ]
Candi, Eleonora [1 ]
Jia, Wei [3 ,4 ]
Bernassola, Francesca [1 ]
Bove, Pierluigi [1 ]
Piacentini, Mauro [1 ]
Scimeca, Manuel [1 ]
Sica, Giuseppe [1 ]
Tisone, Giuseppe [1 ]
Mauriello, Alessandro [1 ]
Wei, Lixin [5 ,6 ]
Melino, Gerry [1 ]
Shi, Yufang [2 ]
机构：
[1] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome, Italy
[2] Soochow Univ, Affiliated Hosp 3, Inst Translat Med, Med Coll,State Key Lab Radiat Med & Protect, Suzhou, Jiangsu, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Ctr Translat Med, Sch Med,Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China
[4] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
[5] Naval Med Univ, Affiliated Hosp 3, Dept Tumor Immunol, Shanghai 200438, Peoples R China
[6] Naval Med Univ, Affiliated Hosp 3, Gene Therapy Ctr, Shanghai 200438, Peoples R China
来源：
BIOLOGY DIRECT | 2023年 / 18卷 / 01期
关键词：
Mesenchymal stem cells; Inflammation; MSC Therapy; SMALL EXTRACELLULAR VESICLES; STROMAL CELLS; INNATE IMMUNITY; ADIPOSE-TISSUE; DIFFERENTIATION; SENESCENCE; MIGRATION; STRESS; EXPRESSION; INDUCTION;
D O I：
10.1186/s13062-023-00394-6
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and "inflammaging". Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the "inflammaging" and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.
引用
收藏
页数：12
相关论文
共 164 条
  • [1] Purification and characterization of glutathione transferases from the sea bass (Dicentrarchus labrax) liver
    Angelucci, S
    Sacchetta, P
    Moio, P
    Melino, S
    Petruzzelli, R
    Gervasi, P
    Di Ilio, C
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2000, 373 (02) : 435 - 441
  • [2] p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation
    Artigas, Natalia
    Gamez, Beatriz
    Cubillos-Rojas, Monica
    Sanchez-de Diego, Cristina
    Antonio Valer, Jose
    Pons, Gabriel
    Luis Rosa, Jose
    Ventura, Francesc
    [J]. CELL DEATH AND DIFFERENTIATION, 2017, 24 (12) : 2022 - 2031
  • [3] Lifestyle-dependent microglial plasticity: training the brain guardians
    Augusto-Oliveira, Marcus
    Verkhratsky, Alexei
    [J]. BIOLOGY DIRECT, 2021, 16 (01)
  • [4] In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors
    Baek, Sun Jin
    Kang, Sung Keun
    Ra, Jeong Chan
    [J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2011, 43 (10) : 596 - 603
  • [5] Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
    Baker, Darren J.
    Childs, Bennett G.
    Durik, Matej
    Wijers, Melinde E.
    Sieben, Cynthia J.
    Zhong, Jian
    Saltness, Rachel A.
    Jeganathan, Karthik B.
    Verzosa, Grace Casaclang
    Pezeshki, Abdulmohammad
    Khazaie, Khashayarsha
    Miller, Jordan D.
    van Deursen, Jan M.
    [J]. NATURE, 2016, 530 (7589) : 184 - +
  • [6] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    Baker, Darren J.
    Wijshake, Tobias
    Tchkonia, Tamar
    LeBrasseur, Nathan K.
    Childs, Bennett G.
    van de Sluis, Bart
    Kirkland, James L.
    van Deursen, Jan M.
    [J]. NATURE, 2011, 479 (7372) : 232 - U112
  • [7] Characterization of bone marrow-derived mesenchymal stem cells in aging
    Baker, Natasha
    Boyette, Lisa B.
    Tuan, Rocky S.
    [J]. BONE, 2015, 70 : 37 - 47
  • [8] Aging, inflammation and the environment
    Bektas, Arsun
    Schurman, Shepherd H.
    Sen, Ranjan
    Ferrucci, Luigi
    [J]. EXPERIMENTAL GERONTOLOGY, 2018, 105 : 10 - 18
  • [9] New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes
    Betancourt, Aline M.
    [J]. MESENCHYMAL STEM CELLS: BASICS AND CLINICAL APPLICATION II, 2013, 130 : 163 - 197
  • [10] Aging of mesenchymal stem cell in vitro
    Bonab, MM
    Alimoghaddam, K
    Talebian, F
    Ghaffari, SH
    Ghavamzadeh, A
    Nikbin, B
    [J]. BMC CELL BIOLOGY, 2006, 7 (1)
12345678910