Inflammation, stress and depression: An exploration of ketamine's therapeutic profile

被引：23
作者：
Johnston, Jenessa N. [1 ]
Greenwald, Maximillian S. [1 ]
Henter, Ioline D. [1 ]
Kraus, Christoph [1 ]
Mkrtchian, Anahit [1 ]
Clark, Neil G. [2 ]
Park, Lawrence T. [1 ]
Gold, Philip [1 ]
Zarate, Carlos A. Zarate [1 ]
Kadriu, Bashkim [1 ]
机构：
[1] NIMH, NIH, Expt Therapeut & Pathophysiol Branch, Bethesda, MD 20892 USA
[2] Uniformed Serv Univ Hlth Sci, US Sch Med, Bethesda, MD USA
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Ketamine; depression; stress; inflammation; treatment-resistant depression; anhedonia; TREATMENT-RESISTANT DEPRESSION; C-REACTIVE PROTEIN; NF-KAPPA-B; ANIMAL-MODELS; MICROGLIAL ACTIVATION; SERUM INTERLEUKIN-6; KYNURENINE PATHWAY; DOWN-REGULATION; DOUBLE-BLIND; GLUTAMATE;
D O I：
10.1016/j.drudis.2023.103518
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Well-established animal models of depression have described a proximal relationship between stress and central nervous system (CNS) inflammation - a relationship mirrored in the peripheral inflammatory biomarkers of individuals with depression. Evidence also suggests that stress-induced proin-flammatory states can contribute to the neurobiology of treatment-resistant depression. Interestingly, ketamine, a rapid-acting antidepressant, can partially exert its therapeu-tic effects via anti-inflammatory actions on the hypothala-mic-pituitary adrenal (HPA) axis, the kynurenine pathway or by cytokine suppression. Further investigations into the relationship between ketamine, inflammation and stress could provide insight into ketamine's unique therapeutic mechanisms and stimulate efforts to develop rapid-acting, anti-inflammatory-based antidepressants.
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页数：13
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