Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome

被引:12
作者
Moradi, Nariman [1 ,2 ]
Fadaei, Reza [3 ]
Roozbehkia, Maryam [4 ]
Nourbakhsh, Mitra [5 ,6 ]
Nourbakhsh, Mona [7 ]
Razzaghy-Azar, Maryam [2 ]
Larijani, Bagher [8 ]
机构
[1] Kurdistan Univ Med Sci, Res Inst Hlth Dev, Liver & Digest Res Ctr, Sanandaj, Iran
[2] Univ Tehran Med Sci, Mol Cellular Sci Inst, Metab Disorders Res Ctr, Endocrinol & Metab, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran
[4] Iran Univ Med Sci, Fac Allied Med Sci, Dept Med Lab Sci, Tehran, Iran
[5] Iran Univ Med Sci, Finetech Med Res Ctr, Tehran, Iran
[6] Iran Univ Med Sci, Sch Med, Dept Biochem, Tehran, Iran
[7] Iran Univ Med Sci, Hazrat Aliasghar Hosp, Sch Med, Tehran, Iran
[8] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran
关键词
Metrnl; asprosin; obesity; metabolic syndrome; insulin resistance; children; HOMEOSTASIS MODEL ASSESSMENT; SERUM-LEVELS; PPAR-GAMMA; METRNL;
D O I
10.1093/labmed/lmac152
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objective Two newly discovered adipokines, including Meteorin-like protein (Metrnl) and asprosin, have been implicated in glucose and insulin metabolism. This study aimed to investigate the associations of these adipokines with obesity in children and adolescents. Methods This study was performed on 35 normal-weight children and 35 children with obesity. Anthropometric and biochemical parameters were determined. Serum concentrations of Metrnl, asprosin, and insulin were measured using enzyme-linked immunosorbent assay. Results Metrnl level was significantly lower in obese children than normal-weight children. Additionally, Metrnl was negatively correlated with body mass index (BMI), insulin, waist-to-hip ratio, and homeostatic model assessment of insulin resistance (HOMA-IR). Our results also revealed that circulating asprosin levels were significantly increased in obese children compared to the control subjects and were positively correlated with BMI, insulin, HOMA-IR, cholesterol, and LDL-C. Conclusion Obesity is accompanied by significant alterations in Metrnl and asprosin and therefore these adipokines, especially Metrnl, are suggested as new promising therapeutic targets for obesity and its associated metabolic imbalances.
引用
收藏
页码:457 / 463
页数:7
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