BRCA 1/2 mutations and risk of uterine cancer: a systematic review and meta-analysis

被引：0

作者：

Zakerinasab, Faezeh ^{[1
]}

Behfar, Qumars ^{[2
,3
]}

Parsaee, Reza ^{[4
]}

Zadeh, Reza Hossein ^{[5
]}

Foroughi, Elaheh ^{[6
]}

Amirbeik, Amirhesam ^{[7
]}

Ahmadi, Ghazalehsadat ^{[1
]}

机构：

[1] Mashhad Univ Med Sci, Mashhad, Iran

[2] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany

[3] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[4] Shiraz Univ Med Sci, Transplant Res Ctr, Shiraz, Iran

[5] Mashhad Univ Med Sci, Students Res Comm, Fac Med, Mashhad, Iran

[6] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran

[7] Mashhad Univ Med Sci, Student Res Comm, Sch Med, Mashhad, Iran

来源：

BMC GENOMIC DATA | 2024年 / 25卷 / 01期

关键词：

BRCA1; BRCA2; Mutation; Uterine cancer; Endometrial; ENDOMETRIAL CANCER; GERMLINE MUTATIONS; SEROUS CARCINOMA; JEWISH PATIENTS; WOMEN; PANELS;

D O I：

10.1186/s12863-024-01189-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose In this study, we aim to investigate the association between BRCA1/2 mutation and uterine cancer incidence. Material and method We systematically searched three databases including PubMed, Scopus, and Google Scholar up to August 2023; and reviewed 23 cohorts and cross-sectional studies to explore the association between BRCA1/2 mutations and uterine cancer incidence. Results This systematic review comprised a total of 21 cohort studies and 2 cross-sectional studies after the screening process. According to meta-analysis the prevalence of the BRCA1/2 gene in patients with uterine cancer was 0.02 (95%CI = [0.01,0.03], P < 0.01, I-2 = 94.82%) Conclusions Our meta-analysis investigates a 2% prevalence of BRCA1/2 mutation in patients with uterine cancer. Patients with BRCA1/2 mutations might be more conscious of uterine malignancies.

引用

页数：11

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