Priorities in Cardio-Oncology Basic and Translational Science GCOS 2023 Symposium Proceedings: JACC: CardioOncology State-of-the-Art Review

被引：19

作者：

Salloum, Fadi N. ^{[1
]}

Tocchetti, Carlo G. ^{[2
]}

Ameri, Pietro ^{[3
,4
]}

Ardehali, Hossein ^{[5
]}

Asnani, Aarti ^{[6
,7
]}

de Boer, Rudolf A. ^{[8
]}

Burridge, Paul ^{[9
]}

Cabrera, Jose-Angel ^{[10
]}

de Castro, Javier ^{[11
]}

Cordoba, Raul ^{[12
]}

Costa, Ambra ^{[3
]}

Dent, Susan ^{[13
]}

Engelbertsen, Daniel ^{[14
]}

Fernandez-Velasco, Maria ^{[15
]}

Fradley, Mike ^{[16
,17
]}

Fuster, Jose J. ^{[18
]}

Galan-Arriola, Carlos ^{[18
]}

Garcia-Lunar, Ines ^{[18
]}

Ghigo, Alessandra ^{[19
]}

Gonzalez-Neira, Anna ^{[20
]}

Hirsch, Emilio ^{[19
]}

Ibanez, Borja ^{[18
]}

Kitsis, Richard N. ^{[21
,22
,23
,24
]}

Konety, Suma ^{[9
]}

Lyon, Alexander R. ^{[25
]}

Martin, Pilar ^{[18
]}

Mauro, Adolfo G. ^{[1
]}

Mazo Vega, Manuel M. ^{[26
]}

Meijers, Wouter C. ^{[8
]}

Neilan, Tomas G. ^{[27
]}

Rassaf, Tienush ^{[28
]}

Ricke-Hoch, Melanie ^{[29
]}

Sepulveda, Pilar ^{[30
,31
]}

Thavendiranathan, Paaladinesh ^{[32
]}

van der Meer, Peter ^{[33
]}

Fuster, Valentin ^{[18
,34
]}

Ky, Bonnie ^{[17
]}

Lopez-Fernandez, Teresa ^{[35
]}

机构：

[1] Virginia Commonwealth Univ, Div Cardiol, Dept Internal Med, Pauley Heart Ctr, Richmond, VA USA

[2] Univ Naples Federico II, Interdept Ctr Clin & Translat Sci, Interdept Hypertens Res Ctr, Ctr Basic & Clin Immunol Res,Dept Translat Med Sc, Naples, Italy

[3] IRCCS Osped Policlin San Martino, Cardiac Thorac & Vasc Dept, Genoa, Italy

[4] Univ Genoa, Dept Internal Med, Genoa, Italy

[5] Northwestern Univ, Feinberg Cardiovasc Res Inst, Sch Med, Chicago, IL USA

[6] Beth Israel Deaconess Med Ctr, Div Cardiovasc Med, Boston, MA USA

[7] Harvard Med Sch, Boston, MA USA

[8] Erasmus MC, Ctr Thorax, Dept Cardiol, Cardiovasc Inst, Rotterdam, Netherlands

[9] Univ Minnesota, Dept Med, Div Cardiovasc, Minneapolis, MN USA

[10] European Univ Madrid, Hosp Univ Quironsalud Madrid, Dept Cardiol, Madrid, Spain

[11] La Paz Univ Hosp, Hosp La Paz Inst Hlth Res, Ctr Invest Biomed Red Canc, Dept Med Oncol, Madrid, Spain

[12] Fdn Jimenez Diaz Univ Hosp, Hlth Res Inst, Inst Invest Sanitaria Fdn Jimenez Diaz, Madrid, Spain

[13] Duke Univ, Duke Canc Inst, Dept Med, Durham, NC USA

[14] Lund Univ, Cardiovasc Res Immune Regulat, Dept Clin Sci, Malmo, Sweden

[15] Hosp La Paz Inst Hlth Res, Ctr Invest Biomed Red Enfermedades Cardiovasc, Madrid, Spain

[16] Univ Penn, Thalheimer Ctr Cardiooncol, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA USA

[17] Univ Penn, Div Cardiol, Dept Med, Perelman Sch Med, Philadelphia, PA USA

[18] Ctr Invest Biomed Red Enfermedades Cardiovasc, Ctr Nacl Invest Cardiovasc, Madrid, Spain

[19] Univ Torino, Mol Biotechnol Ctr Guido Tarone, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

[20] Spanish Natl Canc Res Ctr, Human Genotyping Unit, Spanish Natl Genotyping Ctr, Human Canc Genet Programme, Madrid, Spain

[21] Albert Einstein Coll Med, Dept Med, Bronx, NY USA

[22] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY USA

[23] Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Bronx, NY USA

[24] Montefiore Einstein Comprehens Canc Ctr, Bronx, NY USA

[25] Royal Brompton Hosp, Cardiooncol Serv, London, England

[26] Cima Univ Navarra, Div Adv Technol, Pamplona, Spain

[27] Harvard Med Sch, Massachusetts Gen Hosp, Cardiooncol Program, Boston, MA USA

[28] Univ Duisburg Essen, West German Heart & Vasc Ctr, Dept Cardiol & Vasc Med, Essen, Germany

[29] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany

[30] Hlth Res Inst Hosp La Fe, Regenerat Med & Heart Transplantat Unit, Valencia, Spain

[31] Carlos III Inst Hlth, Ctr Invest Biomed Red Enfermedades Cardiovasc, Madrid, Spain

[32] Univ Toronto, Univ Hlth Network, Ted Rogers Program Cardiotox Prevent, Toronto Gen Hosp,Div Cardiol,Dept Med,Peter Munk, Toronto, ON, Canada

[33] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[34] Icahn Sch Med Mt Sinai, Zena & Michael Wiener Cardiovasc Inst, New York, NY USA

[35] La Paz Univ Hosp, Hosp La Paz Inst Hlth Res, Dept Cardiol, Madrid, Spain

来源：

JACC: CARDIOONCOLOGY | 2023年 / 5卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

anthracyclines; basic research; cancer; cardiac arrhythmias; cardio-oncology; cardiotoxicity; chemotherapy; immunotherapy; translational research; targeted therapies; ANTHRACYCLINE-INDUCED CARDIOTOXICITY; VENTRICULAR-ARRHYTHMIAS; ATRIAL-FIBRILLATION; HEART-FAILURE; BREAST-CANCER; CARDIOVASCULAR TOXICITIES; CLONAL HEMATOPOIESIS; T-CELLS; SENESCENCE; SURVIVORS;

D O I：

10.1016/j.jaccao.2023.08.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite improvements in cancer survival, cancer therapy-related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to improve patient outcomes, and the bidirectional challenges of translating basic research to clinical care. We acknowledge that there are many additional therapies that are of significance but were not topics of discussion at this symposium. We hope that through this symposium-based review we can highlight the knowledge gaps and clinical priorities to inform the design of future studies that aim to prevent and mitigate cardiovascular disease in cancer patients and survivors. (c) 2023 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：715 / 731

页数：17

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