Visible light-mediated direct C8-H arylation of quinolines and C2-H arylation of quinoline-N-oxides and pyridines under organic photocatalysis

被引：1

作者：

Banu, Saira ^{[1
,2
]}

Singh, Kuldeep ^{[1
,2
]}

Yadav, Prem P. ^{[1
,2
]}

机构：

[1] CSIR, Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, India

[2] Acad Sci & Innovat Res, Ghaziabad 201002, India

来源：

NEW JOURNAL OF CHEMISTRY | 2024年 / 48卷 / 04期

关键词：

C-H ARYLATION; RH(I)-CATALYZED DIRECT ARYLATION; ELECTRON-DEFICIENT HETEROCYCLES; MILD; FUNCTIONALIZATION; HETEROARENES; ARENES; SALTS; AZINE;

D O I：

10.1039/d3nj04956f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

CH-arylated quinolines have found widespread applications in drug discovery as well as in the field of fine chemicals and material science. Herein, we report a general, transition-metal-free, environmentally friendly photocatalytic strategy for the direct C-H arylation of quinolines and quinoline N-oxides/pyridines selectively at the C-8 and C-2 positions, respectively, using chlorophyll as the organic photocatalyst. This method offers a simple, practical route for direct access to C8-aryl quinolines, C2-aryl pyridines, and quinoline N-oxides. The key advantages of the present protocol include operational simplicity, the use of clean energy sources, low reagent costs, and no requirement of pre-functionalized substrates.

引用

页码：1481 / 1488

页数：8

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