The Role of Mesenchymal Stem Cells in Modulating the Breast Cancer Microenvironment

被引：13

作者：

Zhang, Luxiao ^{[1
,2
]}

机构：

[1] Shandong First Med Univ, Dept Surg Oncol, Cent Hosp, Jinan, Peoples R China

[2] Shandong First Med Univ, Dept Surg Oncol, Cent Hosp, Jinan 250001, Shan Dong, Peoples R China

来源：

CELL TRANSPLANTATION | 2023年 / 32卷

关键词：

mesenchymal stem cells; breast cancer; tumor microenvironment; ENDOTHELIAL GROWTH-FACTOR; STROMAL CELLS; IN-VITRO; TUMOR PROGRESSION; UP-REGULATION; PROMOTES; DIFFERENTIATION; BONE; PROLIFERATION; INTERLEUKIN-6;

D O I：

10.1177/09636897231220073

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The role of mesenchymal stem cells (MSCs) in the breast tumor microenvironment (TME) is significant and multifaceted. MSCs are recruited to breast tumor sites through molecular signals released by tumor sites. Once in the TME, MSCs undergo polarization and interact with various cell populations, including immune cells, cancer-associated fibroblasts (CAFs), cancer stem cells (CSCs), and breast cancer cells. In most cases, MSCs play roles in breast cancer therapeutic resistance, but there is also evidence that indicates their abilities to sensitize cancer cells to chemotherapy and radiotherapy. MSCs possess inherent regenerative and homing properties, making them attractive candidates for cell-based therapies. Therefore, MSCs can be engineered to express therapeutic molecules or deliver anti-cancer agents directly to tumor sites. Unraveling the intricate relationship between MSCs and the breast TME has the potential to uncover novel therapeutic targets and advance our understanding of breast cancer biology.

引用

页数：23

共 210 条

[1]

Aboulkheyr Es H., 2021, J Cell Physiol, V236

[2] Role of the mesenchymal stem cells derived from adipose tissue in changing the rate of breast cancer cell proliferation and autophagy, in vitro and in vivo [J].

Adelipour, Maryam ;

Allameh, Abdolamir ;

Sheikhi, Abdolkarim ;

Ranjbaran, Mina ;

Naghashpour, Mahshid ;

Nazeri, Zahra ;

Mojiri-Forushani, Hoda ;

Golabi, Sahar .

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021, 24 (02) :98-107

[3] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[4] Breast cancer cell mesenchymal transition and metastasis directed by DAP5/eIF3d-mediated selective mRNA translation [J].

Alard, Amandine ;

Katsara, Olga ;

Rios-Fuller, Tiffany ;

de la Parra, Columba ;

Ozerdem, Ugur ;

Ernlund, Amanda ;

Schneider, Robert J. .

CELL REPORTS, 2023, 42 (06)

[5] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[6]

Ando S., 2011, Nat Rev Endocrinol, V8

[7] Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts [J].

Andreucci, Elena ;

Fioretto, Bianca Saveria ;

Rosa, Irene ;

Matucci-Cerinic, Marco ;

Biagioni, Alessio ;

Romano, Eloisa ;

Calorini, Lido ;

Manetti, Mirko .

CELLS, 2023, 12 (06)

[8] Hepatocyte Differentiation from iPSCs or MSCs in Decellularized Liver Scaffold: Cell-ECM Adhesion, Spatial Distribution, and Hepatocyte Maturation Profile [J].

Antarianto, Radiana Dhewayani ;

Pragiwaksana, Adrian ;

Septiana, Wahyunia Likhayati ;

Mazfufah, Nuzli Fahdia ;

Mahmood, Ameer .

ORGANOGENESIS, 2022, 18 (01)

[9] Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors [J].

Bajetto, Adriana ;

Pattarozzi, Alessandra ;

Corsaro, Alessandro ;

Barbieri, Federica ;

Daga, Antonio ;

Bosio, Alessia ;

Gatti, Monica ;

Pisaturo, Valerio ;

Sirito, Rodolfo ;

Florio, Tullio .

FRONTIERS IN CELLULAR NEUROSCIENCE, 2017, 11

[10]

Bartosh TJ., 2016, Proc Natl Acad Sci U S A, V113

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