Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study

被引：5

作者：

Kuijpers, Yunus ^{[1
]}

Picavet, H. Susan J. ^{[1
]}

de Rond, Lia ^{[2
]}

de Zeeuw-Brouwer, Mary-lene ^{[2
]}

Rutkens, Ryanne ^{[2
]}

Gijsbers, Esther ^{[2
]}

Slits, Irene ^{[2
]}

Engelfriet, Peter ^{[1
]}

Buisman, Anne-Marie ^{[2
]}

Verschuren, W. M. Monique ^{[1
,3
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Ctr Prevent Lifestyle & Hlth, NL-3721 MA Bilthoven, Netherlands

[2] Natl Inst Publ Hlth & Environm RIVM, Ctr Immunol Infect Dis & Vaccines, NL-3721 MA Bilthoven, Netherlands

[3] Univ Utrecht, Utrecht Med Ctr, Julius Ctr Hlth Sci & Primary Care, NL-3508 TC Utrecht, Netherlands

来源：

IMMUNITY & AGEING | 2023年 / 20卷 / 01期

关键词：

COVID-19; vaccination; Antibody responses; Age; Frailty; Comorbidity; Lifestyle deficits; COVID-19; SEROPOSITIVITY; DISEASES; PROFILE;

D O I：

10.1186/s12979-023-00382-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background Immune responses to vaccination vary widely between individuals. The aim of this study was to identify health-related variables potentially underlying the antibody responses to SARS-CoV-2 vaccination in older persons. We recruited participants in the long-running Doetinchem Cohort Study (DCS) who underwent vaccination as part of the national COVID-19 program, and measured antibody concentrations to SARS-CoV-2 Spike protein (S1) and Nucleoprotein (N) at baseline (T0), and a month after both the first vaccination (T1), and the second vaccination (T2). Associations between the antibody concentrations and demographic variables, including age, sex, socio-economic status (SES), comorbidities (cardiovascular diseases and immune mediated diseases), various health parameters (cardiometabolic markers, inflammation markers, kidney- and lung function) and a composite measure of frailty ('frailty index', ranging from 0 to 1) were tested using multivariate models.Results We included 1457 persons aged 50 to 92 years old. Of these persons 1257 were infection na & iuml;ve after their primary vaccination series. The majority (N = 954) of these individuals were vaccinated with two doses of BNT162b2 (Pfizer) and their data were used for further analysis. A higher frailty index was associated with lower anti-S1 antibody responses at T1 and T2 for both men (R-T1 = -0.095, P-T1 = 0.05; R-T2 = -0.11, P-T2 = 0.02) and women (R-T1 = -0.24, P-T1 < 0.01; R-T2 = -0.15, P-T2 < 0.01). After correcting for age and sex the frailty index was also associated with the relative increase in anti-S1 IgG concentrations between the two vaccinations (beta = 1.6, P < 0.01). Within the construct of frailty, history of a cardiac catheterization, diabetes, gastrointestinal disease, a cognitive speed in the lowest decile of the population distribution, and impaired lung function were associated with lower antibody responses after both vaccinations.Conclusions Components of frailty play a key role in the primary vaccination response to the BNT162b2 vaccine within an ageing population. Older persons with various comorbidities have a lowered immune response after their first vaccination, and while frail and sick older persons see a stronger increase after their second vaccination compared to healthy people, they still have a lower antibody response after their second vaccination.

引用

页数：11