Application of sodium caseinate as protein based coating/stabilizing agent in development and optimization of vitamin D3-loaded nanostructured lipid carriers (NLCs)

被引：8
作者：
Barri, Ali [1 ]
Ghanbarzadeh, Babak [1 ,2 ]
Mohammadi, Maryam [3 ,4 ]
Pezeshki, Akram [1 ]
机构：
[1] Univ Tabriz, Fac Agr, Dept Food Sci & Engn, Tabriz 5166616471, Iran
[2] Near East Univ, Fac Engn, Dept Food Engn, POB 99138,Mersin 10, Cyprus, Turkiye
[3] Univ Kurdistan, Fac Agr, Dept Food Sci & Engn, Sanandaj, Iran
[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran
来源：
FOOD HYDROCOLLOIDS | 2023年 / 144卷
关键词：
Nanostructured lipid carrier; Encapsulation; Vitamin D3; Fortification; Natural surfactants; PHYSICOCHEMICAL STABILITY; FORMULATION; OIL;
D O I：
10.1016/j.foodhyd.2023.108747
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Sodium caseinate is a food-grade protein that has several functional properties, such as acting as an emulsifying and stabilizing agent in a colloidal delivery system. Nanostructured lipid carriers (NLCs) have been proven to be highly effective carriers for encapsulating bioactive compounds. In this research, several novel food-grade NLC systems based on sodium caseinate (as a protein surfactant), anhydrous milk fat (as a solid lipid), and vitamin E acetate (as a liquid oil) were developed as an encapsulant for vitamin D3. The D-optimal combined design was employed to optimize the effects of lipid phase ratios and protein concentrations on particle size and loading efficiency. The optimized formulation obtained from the predicted model was composed of 1% w/v caseinate protein and a 73.23/26.78 solid lipid/liquid oil ratio with a desirability function of 0.983. This optimum formulation showed the smallest particle size at 120.16 nm with a narrow size distribution of 0.208 and an encapsulation efficiency of 96.14%. The cytotoxicity study showed that the anticancer effect of the vitamin was improved after incorporation into the NLC structure. The current study suggests that this composition of biopolymeric surfactant and applied lipid matrix could be an effective, health-promoting, and promising carrier system for developing food-grade bioactive delivery systems.
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页数：10
相关论文
共 40 条
[1]   Vitamin D3/phospholipid complex decorated caseinate nanomicelles for targeted delivery of synergistic combination therapy in breast cancer [J].
Agwa, Mona M. ;
Abu-Serie, Marwa M. ;
Abdelmonsif, Doaa A. ;
Moussa, Nermine ;
Elsayed, Hassan ;
Khattab, Sherine N. ;
Sabra, Sally .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 607
[2]   Chitosan coated liposome dispersions loaded with cacao hull waste extract: Effect of spray drying on physico-chemical stability and in vitro bioaccessibility [J].
Altin, Gokce ;
Gultekin-Ozguven, Mine ;
Ozcelik, Beraat .
JOURNAL OF FOOD ENGINEERING, 2018, 223 :91-98
[3]   Isothermal crystallization of anhydrous milk fat in presence of free fatty acids and their esters: From nanostructure to textural properties [J].
Bayard, Mathilde ;
Kauffmann, Brice ;
Vauvre, Jean-Michael ;
Leal-Calderon, Fernando ;
Cansell, Maud .
FOOD CHEMISTRY, 2022, 366
[4]   Solid lipid nanoparticles stabilized by sodium caseinate and lactoferrin [J].
Bernardes Oliveira, Davi Rocha ;
Furtado, Guilherme de Figueiredo ;
Cunha, Rosiane Lopes .
FOOD HYDROCOLLOIDS, 2019, 90 :321-329
[5]   Design and evaluation of cabazitaxel loaded NLCs against breast cancer cell lines [J].
Chand, Pallavi ;
Kumar, Hitesh ;
Badduri, Nihal ;
Gupta, N. Vishal ;
Bettada, Vidya G. ;
Madhunapantula, SubbaRao, V ;
Kesharwani, Siddharth S. ;
Dey, Surajit ;
Jain, Vikas .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2021, 199 (199)
[6]   Effect of Vitamin D3 Supplements on Development of Advanced Cancer A Secondary Analysis of the VITAL Randomized Clinical Trial [J].
Chandler, Paulette D. ;
Chen, Wendy Y. ;
Ajala, Oluremi N. ;
Hazra, Aditi ;
Cook, Nancy ;
Bubes, Vadim ;
Lee, I-Min ;
Giovannucci, Edward L. ;
Willett, Walter ;
Buring, Julie E. ;
Manson, JoAnn E. .
JAMA NETWORK OPEN, 2020, 3 (11)
[7]   Preparation and characterization of a nanostructured lipid carrier for a poorly soluble drug [J].
Chen, Yiyin ;
Yang, Xiaomin ;
Zhao, Lin ;
Almasy, Laszlo ;
Garamus, Vasil M. ;
Willumeit, Regine ;
Zou, Aihua .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2014, 455 :36-43
[8]   Bone regeneration in a mouse model of type 1 diabetes: Influence of sex, vitamin D3, and insulin [J].
Cignachi, Natalia P. ;
Ribeiro, Alice ;
Machado, Gustavo D. B. ;
Cignachi, Amanda P. ;
Kist, Luiza W. ;
Bogo, Mauricio R. ;
Silva, Rodrigo B. M. ;
Campos, Maria M. .
LIFE SCIENCES, 2020, 263
[9]   Novel approach for overcoming the stability challenges of lipid-based excipients. Part 3: Application of polyglycerol esters of fatty acids for the next generation of solid lipid nanoparticles [J].
Corzo, Carolina ;
Meindl, Claudia ;
Lochmann, Dirk ;
Reyer, Sebastian ;
Salar-Behzadi, Sharareh .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2020, 152 :44-55
[10]  
Ghanbarzadeh B, 2019, NANOCAP FOOD INDUSTR, V2, P179, DOI 10.1016/B978-0-12-815673-5.00006-4
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