The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case-control study

被引：3

作者：

Sideli, Lucia ^{[1
,2
,3
]}

Aas, Monica ^{[2
,4
,5
,6
,7
]}

Quattrone, Diego ^{[4
]}

La Barbera, Daniele ^{[3
]}

La Cascia, Caterina ^{[3
]}

Ferraro, Laura ^{[3
]}

Alameda, Luis ^{[2
,8
,9
,10
]}

Velthorst, Eva ^{[11
]}

Trotta, Giulia ^{[2
]}

Tripoli, Giada ^{[2
,3
,12
]}

Schimmenti, Adriano ^{[13
]}

Fontana, Andrea ^{[1
]}

Gayer-Anderson, Charlotte ^{[14
,15
]}

Stilo, Simona ^{[2
,16
]}

Seminerio, Fabio ^{[3
]}

Sartorio, Crocettarachele ^{[3
]}

Marrazzo, Giovanna ^{[3
]}

Lasalvia, Antonio ^{[17
]}

Tosato, Sarah

Tarricone, Ilaria ^{[18
]}

Berardi, Domenico ^{[19
]}

D'Andrea, Giuseppe ^{[19
]}

Arango, Celso ^{[20
]}

Arrojo, Manuel ^{[21
]}

Bernardo, Miguel ^{[22
,23
]}

Bobes, Julio ^{[24
]}

Sanjuan, Julio ^{[25
]}

Santos, Jose Luis ^{[26
]}

Menezes, Paulo Rossi ^{[27
]}

Del-Ben, Cristina Marta ^{[28
]}

Jongsma, Hannah E. ^{[29
,30
]}

Jones, Peter B. ^{[31
,32
]}

Kirkbride, James B. ^{[29
]}

Llorca, Pierre-Michel ^{[32
]}

Tortell, Andrea ^{[33
]}

Pignon, Baptiste ^{[34
,35
,36
]}

de Haan, Lieuwe ^{[37
]}

Selten, Jean-Paul ^{[38
,39
]}

Van Os, Jim ^{[2
,39
,40
]}

Rutten, Bart P. ^{[39
]}

Bentall, Richard ^{[41
]}

Di Fort, Marta ^{[4
]}

Murray, Robin M. ^{[2
]}

Morgan, Craig ^{[14
,15
]}

Fisher, Helen L. ^{[15
]}

机构：

[1] LUMSA Univ, Dept Human Sci, Piazza Vaschette 101, I-00193 Rome, Italy

[2] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[3] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social & Genet & Dev Psychiat Ctr, London, England

[5] Oslo Univ Hosp, NORMENT Ctr Psychosis Res, Oslo, Norway

[6] Univ Oslo, Oslo, Norway

[7] Oslo Metropolitan Univ, Dept Behav Sci, OsloMet, Oslo, Norway

[8] Ctr Invest Biomed Red Salud Mental CIBERSAM, Seville, Spain

[9] Univ Seville, Hosp Univ Virgen Rocio, Dept Psiquiatria, Inst Biomed Sevilla IBIS, Seville, Spain

[10] Lausanne Univ Hosp CHUV, Serv Gen Psychiat Treatment & Early Intervent Psy, Lausanne, Switzerland

[11] Mental Hlth Serv Org GGZ Noord Holland Noord, Dept Res, Hoorn, Netherlands

[12] Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, Palermo, Italy

[13] UKE Kore Univ Enna, Fac Human & Social Sci, Enna, Italy

[14] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Hlth Serv & Populat Res, London, England

[15] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England

[16] ASP Crotone, Dept Mental Hlth & Addict Serv, Crotone, Italy

[17] Univ Verona, Dept Neurosci Biomed & Movement, Sect Psychiat, Verona, Italy

[18] Alma Mater Studiorum Bologna Univ, Dept Med & Surg Sci, Bologna, Italy

[19] Alma Mater Studiorum Bologna Univ, Dept Biomed & NeuroMotor Sci, Psychiat Unit, Bologna, Italy

[20] Univ Complutense, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Sch Med,Dept Child & Adolescent Psychiat,ISGM,CIB, Madrid, Spain

[21] Complejo Hosp Univ Santiago de Compostela, Inst Invest Sanitaria Santiago de Compostela, Dept Psychiat, Psychiat Genet Grp, Santiago, Spain

[22] Univ Barcelona UB, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Inst Neurociencies UBNeuro, Hosp Clin,Dept Med,Barcelona Clin Schizophrenia U, Barcelona, Spain

[23] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

[24] Univ Oviedo, Ctr Invest Biomed Red Salud Mental CIBERSAM, Sch Med, Dept Med,Psychiat Area,ISPA,INEUROPA, Oviedo, Spain

[25] Univ Valencia, Ctr Invest Biomed Red Salud Mental, Sch Med, Dept Psychiat, Valencia, Spain

[26] Hosp Virgen de La Luz, Dept Psychiat, Cuenca, Spain

[27] Univ Sao Paulo, Fac Med, Sao Paulo, Brazil

[28] Univ Sao Paulo, Fac Med Ribeirao Preto, Sao Paulo, Brazil

[29] UCL, Div Psychiat, PsyLife Grp, London, England

[30] Univ Cambridge, Dept Psychiat, Cambridge, England

[31] Cambridgeshire & Peterborough Natl Hlth Serv Fdn, CAMEO Early Intervent Serv, Cambridge, England

[32] Univ Clermont Auvergne, EA 7280 Npsydo, Clermont Ferrand, France

[33] Maison Blanche, Estab Publ Sante, Paris, France

[34] AP HP, Grp Hosp Mondor, Pole Psychiat, Creteil, France

[35] Inst Natl Sante & Rech Med, U955, Creteil, France

[36] Fdn FondaMental, Creteil, France

[37] Amsterdam UMC, Dept Psychiat, Early Psychosis Sect, Amsterdam, Netherlands

[38] GGZ Rivierduinen, Inst Mental Hlth, Leiden, Netherlands

[39] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht, Netherlands

[40] Univ Utrecht, Dept Psychiat, Med Ctr, Utrecht, Netherlands

[41] Univ Sheffield, Dept Psychol, 1 Vicar Lane, Sheffield S1 2LT, England

来源：

SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY | 2023年 / 58卷 / 10期

基金：

欧盟地平线“2020”; 美国国家卫生研究院; 英国经济与社会研究理事会; 英国医学研究理事会;

关键词：

Childhood adversity; Cognition; Family history of psychosis; First episode; Polygenic risk score; Psychosis; FAMILIAL RISK; TRAUMA; SCHIZOPHRENIA; COGNITION; INTERPLAY; VALIDITY; MODERATE; OVERLAP; ABILITY; ONSET;

D O I：

10.1007/s00127-023-02513-0

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.

引用

页码：1573 / 1580

页数：8

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