Defining the pediatric response to SARS-CoV-2 variants

被引：5

作者：

Ho, Reanne M. ^{[1
,2
,3
]}

Bowen, Asha C. ^{[2
,3
,4
,5
]}

Blyth, Christopher C. ^{[2
,3
,4
]}

Imrie, Allison ^{[2
,6
]}

Kollmann, Tobias R. ^{[4
,7
,8
]}

Stick, Stephen M. ^{[1
,9
,10
,11
]}

Kicic, Anthony ^{[1
,9
,10
,11
,12
]}

机构：

[1] Univ Western Australia, Telethon Kids Inst, Wal Yan Resp Res Ctr, Nedlands, WA, Australia

[2] Univ Western Australia, Med Sch, Nedlands, WA, Australia

[3] Telethon Kids Inst, Wesfarmers Ctr Vaccines & Infect Dis, Nedlands, WA, Australia

[4] Perth Childrens Hosp, Dept Infect Dis, Nedlands, WA, Australia

[5] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, Australia

[6] Univ Western Australia, Sch Biomed Sci, Nedlands, WA, Australia

[7] Univ Western Australia, Telethon Kids Inst, Nedlands, WA, Australia

[8] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada

[9] Perth Childrens Hosp, Dept Resp & Sleep Med, Perth, WA, Australia

[10] Univ Western Australia, Ctr Cell Therapy & Regenerat Med, Sch Med & Pharmacol, Nedlands, WA, Australia

[11] Harry Perkins Inst Med Res, Nedlands, WA, Australia

[12] Curtin Univ, Sch Populat Hlth, Perth, WA, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

COVID-19; SARS-CoV-2; pediatric; children; emerging variants; molecular biology; cellular biology; age-specific response;

D O I：

10.3389/fimmu.2023.1200456

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The global population has been severely affected by the coronavirus disease 2019 (COVID-19) pandemic, however, with older age identified as a risk factor, children have been underprioritized. This article discusses the factors contributing to the less severe response observed in children following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including, differing viral entry receptor expression and immune responses. It also discusses how emerging and future variants could present a higher risk to children, including those with underlying comorbidities, in developing severe disease. Furthermore, this perspective discusses the differential inflammatory markers between critical and non-critical cases, as well as discussing the types of variants that may be more pathogenic to children. Importantly, this article highlights where more research is urgently required, in order to protect the most vulnerable of our children.

引用

页数：8

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