Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

被引：12
作者：
Ma, Panqin [1 ]
Wang, Qi [1 ]
Luo, Xi [2 ]
Mao, Liuzhou [1 ]
Wang, Zhanxiang [2 ]
Ye, Enyi [3 ,4 ]
Loh, Xian Jun [3 ,4 ]
Li, Zibiao [3 ,4 ,5 ]
Wu, Yun-Long [1 ]
机构：
[1] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China
[2] Xiamen Univ, Affiliated Hosp 1, BE Phase Clin Ctr 1, Sch Med, Xiamen 361000, Peoples R China
[3] ASTAR, Inst Mat Res & Engn, 2 Fusionopolis Way, Innovis, 08-03, Singapore 138634, Singapore
[4] ASTAR, Inst Sustainabil Chem Energy & Environm ISCE2, 1 Pesek Rd, Singapore 627833, Singapore
[5] Natl Univ Singapore, Dept Mat Sci & Engn, 9,Engn Dr 1, Singapore 117576, Singapore
来源：
BIOMATERIALS SCIENCE | 2023年 / 11卷 / 15期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
CAS9; RIBONUCLEOPROTEIN; CRISPR-CAS9; SYSTEM; MEDIATED DELIVERY; GENOME; NANOCARRIERS; NANOPARTICLES; TECHNOLOGIES; MECHANISMS; MICELLES; RELEASE;
D O I：
10.1039/d3bm00529a
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Non-viral polymeric vectors with good biocompatibility have been recently explored as delivery systems for clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) nucleases. In this review, based on current limitations and critical barriers, we summarize the advantages of stimulus-responsive polymeric delivery vectors (i.e., pH, redox, or enzymes) towards controllable CRISPR/Cas9 genome editing system delivery as well as the advances in using stimulus-responsive CRISPR/Cas9 polymeric carriers towards cancer treatment. Last but not least, the key challenges and promising development strategies of stimulus-responsive polymeric vector designs for CRISPR/Cas9 systems will also be discussed.
引用
收藏
页码：5078 / 5094
页数：17
相关论文
共 95 条
[1]   High Molecular Weight Poly(ethylenimine)-Based Water-Soluble Lipopolymer for Transfection of Cancer Cells [J].
Abd Elhameed, Heba Alaa Hosiny ;
Ungor, Ditta ;
Igaz, Nora ;
Gopisetty, Mohana Krishna ;
Kiricsi, Monika ;
Csapo, Edit ;
Gyurcsik, Bela .
MACROMOLECULAR BIOSCIENCE, 2020, 20 (07)
[2]   Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system [J].
Ahern, Jonathan O'Keeffe ;
Lara-Saez, Irene ;
Zhou, Dezhong ;
Murillas, Rodolfo ;
Bonafont, Jose ;
Mencia, Angeles ;
Garcia, Marta ;
Manzanares, Dario ;
Lynch, Jennifer ;
Foley, Ruth ;
Xu, Qian ;
Sigen, A. ;
Larcher, Fernando ;
Wang, Wenxin .
GENE THERAPY, 2022, 29 (3-4) :157-170
[3]   Theranostic mesoporous silica nanoparticles made of multi-nuclear gold or carbon quantum dots particles serving as pH responsive drug delivery system [J].
Akbarian, Mohsen ;
Gholinejad, Mohammad ;
Mohammadi-Samani, Soliman ;
Farjadian, Fatemeh .
MICROPOROUS AND MESOPOROUS MATERIALS, 2022, 329
[4]   Ru(II)(n6-p-cymene) Conjugates Loaded onto Graphene Oxide: An Effective pH-Responsive Anticancer Drug Delivery System [J].
Akhter, Suffora ;
Arjmand, Farukh ;
Pettinari, Claudio ;
Tabassum, Sartaj .
MOLECULES, 2022, 27 (21)
[5]   Development and evaluation of a pH-responsive and water-soluble drug delivery system based on smart polymer coating of graphene nanosheets: anin silicostudy [J].
Alinejad, Abutaleb ;
Raissi, Heidar ;
Hashemzadeh, Hassan .
RSC ADVANCES, 2020, 10 (52) :31106-31114
[6]   A novel curcumin-loaded PLGA micromagnetic composite system for controlled and pH-responsive drug delivery [J].
Ayyanaar, Srinivasan ;
Kesavan, Mookkandi Palsamy ;
Sivaraman, Gandhi ;
Maddiboyina, Balaji ;
Annaraj, Jamespandi ;
Rajesh, Jegathalaprathaban ;
Rajagopal, Gurusamy .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2019, 573 :188-195
[7]   pH-responsive drug delivery systems as intelligent carriers for targeted drug therapy: Brief history, properties, synthesis, mechanism and application [J].
Bami, Marzieh Sajadi ;
Estabragh, Mohammad Amin Raeisi ;
Khazaeli, Payam ;
Ohadi, Mandana ;
Dehghannoudeh, Gholamreza .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 70
[8]   PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure-function relationships [J].
Beyerle, Andrea ;
Merkel, Olivia ;
Stoeger, Tobias ;
Kissel, Thomas .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2010, 242 (02) :146-154
[9]   A Dual Bioconjugated Virus-Like Nanoparticle as a Drug Delivery System and Comparison with a pH-Responsive Delivery System [J].
Biabanikhankandani, Roya ;
Ho, Kok Lian ;
Alitheen, Noorjahan Banu ;
Tan, Wen Siang .
NANOMATERIALS, 2018, 8 (04)
[10]   A pH-responsive mesoporous silica nanoparticle-based drug delivery system for targeted breast cancer therapy [J].
Chang, Jie ;
Mo, Liufang ;
Song, Jinfeng ;
Wang, Xiaochen ;
Liu, Hanhan ;
Meng, Chenchen ;
Wu, Yijun .
JOURNAL OF MATERIALS CHEMISTRY B, 2022, 10 (17) :3375-3385
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