COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis

被引：77

作者：

Ceban, Felicia ^{[1
,2
,3
]}

Kulzhabayeva, Dana ^{[4
]}

Rodrigues, Nelson B. ^{[1
]}

Di Vincenzo, Joshua D. ^{[1
]}

Gill, Hartej ^{[1
,10
]}

Subramaniapillai, Mehala ^{[1
,3
]}

Lui, Leanna M. W. ^{[1
,10
]}

Cao, Bing ^{[9
]}

Mansur, Rodrigo B. ^{[1
,5
]}

Ho, Roger C. ^{[7
,8
]}

Burke, Matthew J. ^{[5
,11
,12
]}

Rhee, Taeho Greg ^{[13
,14
]}

Rosenblat, Joshua D. ^{[1
,5
]}

McIntyre, Roger S. ^{[1
,3
,5
,6
,10
,15
]}

机构：

[1] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada

[2] McMaster Univ, Michael G DeGroote Sch Med, Hamilton, ON, Canada

[3] Brain & Cognit Discovery Fdn, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[5] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[6] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore 119228, Singapore

[8] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore 119077, Singapore

[9] Southwest Univ, Fac Psychol, Key Lab Cognit & Personal, Minist Educ, Chongqing 400715, Peoples R China

[10] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[11] Sunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON, Canada

[12] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Div Cognit Neurol, Boston, MA USA

[13] Yale Sch Med, Dept Psychiat, New Haven, CT USA

[14] Univ Connecticut, Sch Med, Dept Publ Hlth Sci, Farmington, CT USA

[15] Suite 600,77 Bloor St W, Toronto, ON M5S 1M2, Canada

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2023年 / 111卷

关键词：

COVID-19; SARS-CoV-2; Long COVID; Post-COVID-19; condition; syndrome; Post-acute sequelae of COVID-19 PASC; Vaccination; Inflammation; Cognition; Prevention; Treatment; Population health; Depression; Bipolar disorder; Mood disorders;

D O I：

10.1016/j.bbi.2023.03.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Empirical evidence addressing the association between SARS-CoV-2 vaccination and long COVID would guide public health priorities and inform personal health decisions. Herein, the co-primary objectives are to determine the differential risk of long COVID in vaccinated versus unvaccinated patients, and the trajectory of long COVID following vaccination. Of 2775 articles identified via systematic search, 17 were included, and 6 were meta -analyzed. Meta-analytic results determined that at least one vaccine dose was associated with a protective ef-fect against long COVID (OR 0.539, 95% CI 0.295-0.987, p = 0.045, N = 257 817). Qualitative analysis revealed that trajectories of pre-existing long COVID following vaccination were mixed, with most patients reporting no changes. The evidence herein supports SARS-CoV-2 vaccination for the prevention of long COVID, and recom-mends long COVID patients adhere to standard SARS-CoV-2 vaccination schedules.

引用

页码：211 / 229

页数：19

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