The role of Klotho and FGF23 in cardiovascular outcomes of diabetic patients with chronic limb threatening ischemia: a prospective study

被引：5

作者：

Biscetti, Federico ^{[1
]}

Rando, Maria Margherita ^{[1
]}

Cecchini, Andrea Leonardo ^{[2
]}

Nicolazzi, Maria Anna ^{[1
]}

Rossini, Enrica ^{[1
]}

Angelini, Flavia ^{[2
]}

Iezzi, Roberto ^{[2
,3
]}

Eraso, Luis H. ^{[4
]}

Dimuzio, Paul J. ^{[4
]}

Pitocco, Dario ^{[2
,5
]}

Gasbarrini, Antonio ^{[2
,6
]}

Massetti, Massimo ^{[2
,7
]}

Flex, Andrea ^{[1
,2
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dept Cardiovasc Sci, Cardiovasc Internal Med, Largo Agostino Gemelli 8, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Largo Francesco Vito 1, I-00168 Rome, Italy

[3] Fdn Policlin Univ A Gemelli, Radiol Unit, IRCCS, Rome, Italy

[4] Thomas Jefferson Univ, Div Vasc & Endovascular Surg, Philadelphia, PA USA

[5] Fdn Policlin Univ A Gemelli, Diabetol Unit, IRCCS, Rome, Italy

[6] Fdn Policlin Univ A Gemelli IRCCS, Dept Med & Surg Sci, Largo Agostino Gemelli 8, I-00168 Rome, Italy

[7] Fdn Policlin Univ A Gemelli IRCCS, Dept Cardiovasc Sci, Largo Agostino Gemelli 8, I-00168 Rome, Italy

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

PERIPHERAL ARTERY-DISEASE; SOLUBLE KLOTHO; PROTECTS; ANGIOGENESIS; ASSOCIATION; MORTALITY; RISK;

D O I：

10.1038/s41598-023-33190-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cardiovascular complications after lower extremity revascularization (LER) are common in diabetic patients with peripheral arterial disease (PAD) and chronic limb threatening ischemia (CLTI). The Klotho-fibroblast growth factor 23 (FGF23) axis is associated with endothelial injury and cardiovascular risk. We aimed to analyze the relationship between Klotho and FGF23 serum levels and the incidence of major adverse cardiovascular events (MACE) and major adverse limb events (MALE) after LER in diabetic patients with PAD and CLTI. Baseline levels of Klotho and FGF23, and their association with subsequent incidence of MACE and MALE were analyzed in a prospective, non-randomized study in a population of diabetic patients with PAD and CLTI requiring LER. A total of 220 patients were followed for 12 months after LER. Sixty-three MACE and 122 MALE were recorded during follow-up period. Baseline lower Klotho serum levels (295.3 +/- 151.3 pg/mL vs. 446.4 +/- 171.7 pg/mL, p < 0.01), whereas increased serum levels FGF23 (75.0 +/- 11.8 pg/mL vs. 53.2 +/- 15.4 pg/mL, p < 0.01) were significantly associated with the development of MACE. Receiver operating characteristic (ROC) analysis confirmed the predictive power of Klotho and FGF23 baseline levels. Furthermore, decreased Klotho levels were associated with the occurrence of MALE after LER (329.1 +/- 136.8 pg/mL vs 495.4 +/- 183.9 pg/mL, p < 0.01). We found that Klotho and FGF23 baseline levels are a potential biomarker for increased cardiovascular risk after LER in diabetic patients with PAD and CLTI.

引用

页数：11

共 47 条

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