The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy

被引：4

作者：

Chen, Rui ^{[1
]}

Liu, Mingxia ^{[2
]}

Jiang, Quanhong ^{[3
]}

Meng, Xiangbo ^{[3
]}

Wei, Junmin ^{[1
]}

机构：

[1] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Med Oncol, Jinan, Shandong, Peoples R China

[2] Tianjin Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Dept Immunol, Tianjin, Peoples R China

[3] Shandong Univ, Adv Med Res Inst, Cheeloo Coll Med, Meili Lake Translat Res Pk, Jinan, Shandong, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

cGAS-STING; tumor; immune regulation; immunotherapy; clinical application; CGAS-STING PATHWAY; ANTITUMOR IMMUNE-RESPONSES; CANCER-CELLS; DNA-DAMAGE; AGONIST; SENESCENCE; TRIGGERS; ACTIVATION; MOUSE; INFLAMMATION;

D O I：

10.3389/fimmu.2023.1121603

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein stimulator of interferon genes (STING), which then activates the kinases IKK and TBK1 to induce the secretion of interferons and other cytokines. Recently, a series of studies demonstrated that the cGAS-STING pathway, a vital component of host innate immunity, might play an important role in anticancer immunity, though its mechanism remains to be elucidated. In this review, we highlight the latest understanding of the cGAS-STING pathway in tumor development and the advances in combination therapy of STING agonists and immunotherapy.

引用

页数：13