Design, Synthesis, and In Vitro Anticancer Activity of Triazolyl Analogs of Abietic Acid

被引：1
|
作者：
Ali, G. [1 ]
Ara, T. [1 ]
机构：
[1] Natl Inst Technol Hazratbal, Srinagar 190006, Jammu & Kashmir, India
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 01期
关键词：
abietic acid; triazole; antitumor agents; cancer cell lines; CLICK CHEMISTRY; BIOLOGICAL EVALUATION; CHALLENGES; 1,2,3-TRIAZOLE; DERIVATIVES; DISCOVERY; STRATEGY; DELIVERY;
D O I：
10.1134/S1070428023010153
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of abietic acid analogs modified with a triazole moiety were synthesized using Huisgen 1,3-dipolar cycloaddition in order to obtain potent antitumor agents. The synthesized compounds and starting materials were tested in vitro against four human cancer cell lines, MDA-MB-231 and MCF-7 (human breast cancer cells), A549 (human lung cancer), PC3 (human prostate cancer), and FR2 (non-tumor human breast epithelial cell line) by MTT assay. Some of the synthesized analogs showed better biological profiles than that of the precursors. The most active compound (4-hydroxyphenyl derivative) showed an IC50 value of 35.4 mu M against MDA-MB-231 cancer cell line.
引用
收藏
页码：142 / 149
页数：8
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