Design, Synthesis, and In Vitro Anticancer Activity of Triazolyl Analogs of Abietic Acid

被引：1

作者：

Ali, G. ^{[1
]}

Ara, T. ^{[1
]}

机构：

[1] Natl Inst Technol Hazratbal, Srinagar 190006, Jammu & Kashmir, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 59卷 / 01期

关键词：

abietic acid; triazole; antitumor agents; cancer cell lines; CLICK CHEMISTRY; BIOLOGICAL EVALUATION; CHALLENGES; 1,2,3-TRIAZOLE; DERIVATIVES; DISCOVERY; STRATEGY; DELIVERY;

D O I：

10.1134/S1070428023010153

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of abietic acid analogs modified with a triazole moiety were synthesized using Huisgen 1,3-dipolar cycloaddition in order to obtain potent antitumor agents. The synthesized compounds and starting materials were tested in vitro against four human cancer cell lines, MDA-MB-231 and MCF-7 (human breast cancer cells), A549 (human lung cancer), PC3 (human prostate cancer), and FR2 (non-tumor human breast epithelial cell line) by MTT assay. Some of the synthesized analogs showed better biological profiles than that of the precursors. The most active compound (4-hydroxyphenyl derivative) showed an IC50 value of 35.4 mu M against MDA-MB-231 cancer cell line.

引用

页码：142 / 149

页数：8