Cardiac Morbidity and Mortality in Patients with Sarcoma: A Population-Based Study

被引：2

作者：

Alanazi, Rakan ^{[1
,2
]}

Aljizeeri, Ahmed ^{[1
,2
,3
]}

Alsaileek, Ahmed ^{[1
,2
,3
]}

Alrashid, Azzam ^{[1
,2
]}

Alolayan, Ashwaq ^{[1
,2
,4
]}

Alkaiyat, Mohammad ^{[1
,2
,4
]}

Alenazy, Basel ^{[2
,3
]}

Shehata, Hussam ^{[1
,2
,4
]}

Alqahtani, Joud ^{[1
,2
,4
]}

Ardah, Husam ^{[1
,5
]}

Alshammari, Kanan ^{[1
,2
,4
]}

机构：

[1] King Saud bin Abdulaziz Univ Hlth Sci KSAU HS, Coll Med, Minist Natl Guard Hlth Affairs, Riyadh, Saudi Arabia

[2] Minist Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[3] Minist Natl Guard Hlth Affairs, King Abdulaziz Cardiac Ctr, Riyadh, Saudi Arabia

[4] Minist Natl Guard Hlth Affairs, Dept Med Oncol, King Abdulaziz Med City, POB 22490, Riyadh 11426, Saudi Arabia

[5] King Abdullah Int Med Res Ctr, Dept Biostat & Bioinformat, Riyadh, Saudi Arabia

来源：

CLINICAL MEDICINE INSIGHTS-ONCOLOGY | 2024年 / 18卷

关键词：

Soft tissue sarcoma; doxorubicin; cardiotoxicity; SOFT-TISSUE SARCOMA; DOXORUBICIN THERAPY; HEART-FAILURE; RISK-FACTORS; TROPONIN-I; CANCER; CARDIOTOXICITY; DYSFUNCTION; PREDICTION; OUTCOMES;

D O I：

10.1177/11795549241237703

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Soft tissue sarcoma (STS) is a rare malignancy that affects soft tissues. It encompasses various subtypes and requires different treatment strategies. Doxorubicin is a commonly used anthracycline in the management of localized and metastatic STS. However, high doses of doxorubicin are associated with cardiotoxicity, which can significantly impact patients' long-term outcomes. This study aimed to evaluate doxorubicin's effect on cardiac function in patients with sarcoma and to correlate the frequency of cardiotoxicity with potential risk factors.Methods: A retrospective analysis was conducted on patients with sarcoma who were treated with doxorubicin between 2016 and 2022 at King Abdulaziz Medical City in Saudi Arabia. Patient demographic information, comorbidities, cardiac measurements, laboratory values, systemic therapy, and treatment outcomes were collected from electronic medical records. A statistical analysis was performed to assess the association between cardiotoxicity and various factors.Results: A total of 133 patients were included in the study, with a median age of 30 years. Cardiotoxicity was observed in 9% of the patients. Female patients had a significantly higher risk of developing cardiotoxicity. Patients with a higher Eastern Cooperative Oncology Group (ECOG) performance status and lower troponin I levels also had an increased risk of cardiotoxicity. However, there was no significant association between cardiotoxicity and the number of chemotherapy cycles, total cumulative dose of doxorubicin, or history of radiation. Furthermore, patients with cardiotoxicity had a higher risk of mortality. The overall survival of the patients was 18 months.Conclusion: Doxorubicin-associated cardiotoxicity is a concern for patients with sarcoma. Female patients and patients with a higher ECOG performance status are at an increased risk of developing cardiotoxicity. Careful monitoring and risk assessment are crucial for mitigating the adverse effects of doxorubicin treatment in patients with sarcoma. Future studies are warranted to validate these findings and explore preventive strategies for doxorubicin-induced cardiotoxicity in patients with sarcoma.

引用

页数：10

共 32 条

[1] The burden and predictors of venous thromboembolic diseases in patients with multiple primary malignancies [J].