Compensated Advanced Chronic Liver Disease and Steatosis in Patients with Type 2 Diabetes as Assessed through Shear Wave Measurements and Attenuation Measurements

被引:0
作者
Barisic-Jaman, Mislav [1 ]
Milosevic, Marko [1 ]
Skurla, Viktoria [1 ]
Dohoczky, David [1 ]
Stojic, Josip [1 ]
Kujundzic, Petra Dinjar [1 ]
Berkovic, Maja Cigrovski [2 ,3 ]
Majic-Tengg, Ana [2 ]
Matijaca, Ana [2 ]
Lucijanic, Tomo [2 ]
Kardum-Pejic, Mirjana [2 ]
Jaksic, Vlatka Pandzic [2 ,4 ]
Marusic, Srecko [2 ,4 ,5 ]
Grgurevic, Ivica [1 ,4 ,5 ]
机构
[1] Univ Hosp Dubrava, Dept Gastroenterol Hepatol & Clin Nutr, Zagreb 10000, Croatia
[2] Univ Hosp Dubrava, Dept Endocrinol Diabet Metab & Clin Pharmacol, Zagreb 10000, Croatia
[3] Univ Zagreb, Fac Kinesiol, Dept Sport & Exercise Med, Zagreb 10000, Croatia
[4] Univ Zagreb, Sch Med, Zagreb 10000, Croatia
[5] Fac Pharm & Biochem, Univ Zagreb, Zagreb 10000, Croatia
关键词
MASLD; diabetes mellitus; ultrasound; elastography; liver fibrosis; liver steatosis; SIMPLE NONINVASIVE INDEX; SIGNIFICANT FIBROSIS; STIFFNESS MEASUREMENT; HEPATITIS; ELASTOGRAPHY; PREVALENCE; CIRRHOSIS; OUTCOMES; PREDICT; RISK;
D O I
10.3390/biomedicines12020323
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Patients with type 2 diabetes (T2D) are at risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD). We investigated the prevalence of compensated advanced chronic liver disease (cACLD) and steatosis in patients with T2D using the new non-invasive diagnostic methods of shear wave measurements (SWMs) and attenuation (ATT) measurements in comparison with those of vibration-controlled transient elastography (VCTE) and the controlled attenuation parameter (CAP), which served as the reference methods. Among 214 T2D patients, steatosis at any grade and cACLD were revealed in 134 (62.6%) and 19 (8.9%) patients, respectively. SWMs showed a high correlation with VCTE (Spearman's rho = 0.641), whereas SWMs produced lower (mean of -0.7 kPa) liver stiffness measurements (LSMs) overall. At a LSM of >11.0 kPa (Youden), SWMs had an AUROC of 0.951 that was used to diagnose cACLD (defined as a LSM of >15 kPa through VCTE) with 84.2% sensitivity and 96.4% specificity. The performance of ATT measurements in diagnosing liver steatosis at any grade (defined as the CAP of >= 274 dB/m) was suboptimal (AUROC of 0.744 at the ATT measurement cut-off of >0.63 dB/cm/MHz (Youden) with 59% sensitivity and 81.2% specificity). In conclusion, the prevalence of liver steatosis and previously unrecognized cACLD in patients with T2D is high and SWMs appear to be a reliable diagnostic method for this purpose, whereas further investigation is needed to optimize the diagnostic performance of ATT measurements.
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页数:16
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