Development of Antibiotic-Protected Antimicrobial Tetracycline-Loaded GU (Guar Gum) Gel for Long-Term Storage

被引:0
作者
Paramasivam, Gokul [1 ]
Dhamodharan, Duraisami [2 ]
Byun, Hun-Soo [3 ]
机构
[1] Saveetha Inst Med & Tech Sci SIMATS, Saveetha Sch Engn, Dept Biotechnol, Chennai 602105, Tamil Nadu, India
[2] King Fahd Univ Petr & Minerals, Ctr Refining & Adv Chem, Dhahran 31261, Saudi Arabia
[3] Chonnam Natl Univ, Dept Chem & Biomol Engn, Yeosu 59626, Jeonnam, South Korea
基金
新加坡国家研究基金会;
关键词
Guar gum; Gels; Tetracycline; Antimicrobial; Encapsulation; S; aureus; E; coli; FOOD; PRESERVATIVES; STABILITY; FILMS;
D O I
10.1007/s11814-024-00090-9
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Gels are widely used in our everyday lives, spanning personal care, cosmetics, oral care, food and beverages, household products, medical supplies, electronics, and arts and crafts. Their adaptable characteristics contribute to improved product performance, user satisfaction, and overall convenience. However, generation of microbial invasion is a common obstacle observed on gels and its formulations. Antibiotic loaded on gels is a better alternative to chemical-based preservative for long-term storage of gels. In this research, the gel was fabricated with two different components with guar gum (GU) and tetracycline (TC) and its antimicrobial ability was tested over a period of time. We conducted morphological analyses that revealed a solid and rough surface on both GU and reduced sign of microbial attack on TC/GU-based gels. Identification of functional groups is observed using Fourier transform infrared (FTIR) spectroscopy that confirms the gel is well hydrated and make it suitable to deliver antimicrobial agents. Antimicrobial ability performed by antibiotics was tested using disc diffusion method. The unloaded GU gel does not exhibit an observed antimicrobial property, whereas GU/TC gel reveals a better antibacterial efficiency on S. aureus compared to E. coli. Our findings suggest that GU/TC gel can effectively safeguard gels from microbial attacks during long-term storage. Furthermore, this GU/TC gel can be used as a drug transport system for bioactive agents in biomedical applications.
引用
收藏
页码:639 / 645
页数:7
相关论文
共 33 条
[1]   Natural protective agents and their applications as bio-preservatives in the food industry: An overview of current and future applications [J].
Amiri, Saber ;
Moghanjougi, Zahra Motalebi ;
Bari, Mahmoud Rezazadeh ;
Khaneghah, Amin Mousavi .
ITALIAN JOURNAL OF FOOD SCIENCE, 2021, 33 (SP1) :55-68
[2]   Physical and antibacterial properties of Chitosan-guar-peppermint gel for improving wound healing [J].
Ansari, Mojtaba ;
Meftahizadeh, Heidar ;
Eslami, Hossein .
POLYMER BULLETIN, 2023, 80 (07) :8133-8149
[3]   MODERN PRESERVATIVES OF MICROBIOLOGICAL STABILITY (REVIEW) [J].
Anurova, M. N. ;
Bakhrushina, E. O. ;
Demina, N. B. ;
Panteleeva, E. S. .
PHARMACEUTICAL CHEMISTRY JOURNAL, 2019, 53 (06) :564-571
[4]  
Bhubhanil S., 2021, SCI REP-UK, V11, P1
[5]   An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection [J].
Boot, Willemijn ;
Foster, Andrew Lewis ;
Guillaume, Olivier ;
Eglin, David ;
Schmid, Tanja ;
D'Este, Matteo ;
Zeiter, Stephan ;
Richards, Robert Geoff ;
Moriarty, Thomas Fintan .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
[6]   A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model [J].
Boot, Willemijn ;
Schmid, Tanja ;
D'Este, Matteo ;
Guillaume, Olivier ;
Foster, Andrew ;
Decosterd, Laurent ;
Richards, Robert G. ;
Eglin, David ;
Zeiter, Stephan ;
Moriarty, Thomas F. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (04)
[7]   Microorganisms attack synthetic polymers in items representing our cultural heritage [J].
Cappitelli, Francesca ;
Sorlini, Claudia .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2008, 74 (03) :564-569
[8]   Inhibition of Staphylococcus aureus LC 554891 by Moringa oleifera Seed Extract either Singly or in Combination with Antibiotics [J].
Enan, Gamal ;
Al-Mohammadi, Abdul-Raouf ;
Mahgoub, Samir ;
Abdel-Shafi, Seham ;
Askar, Eman ;
Ghaly, Mohamed F. ;
Taha, Mohamed A. ;
El-Gazzar, Nashwa .
MOLECULES, 2020, 25 (19)
[9]   An overview on preparation of emulsion-filled gels and emulsion particulate gels [J].
Farjami, Toktam ;
Madadlou, Ashkan .
TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2019, 86 :85-94
[10]   Development of novel active polypropylene based packaging films containing different concentrations of sorbic acid [J].
Fasihnia, Seyedeh Homa ;
Peighambardoust, Seyed Hadi ;
Peighambardoust, Seyed Jamaleddin ;
Oromiehie, Abdulrasoul .
FOOD PACKAGING AND SHELF LIFE, 2018, 18 :87-94