A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

被引：3

作者：

Batoni, Elisa ^{[1
]}

Bonatti, Amedeo Franco ^{[1
]}

De Maria, Carmelo ^{[1
]}

Dalgarno, Kenneth ^{[2
]}

Naseem, Raasti ^{[2
]}

Dianzani, Umberto ^{[3
]}

Gigliotti, Casimiro Luca ^{[3
,4
]}

Boggio, Elena ^{[3
,4
]}

Vozzi, Giovanni ^{[1
]}

机构：

[1] Univ Pisa, Res Ctr E Piaggio, Dept Informat Engn, I-56122 Pisa, Italy

[2] Newcastle Univ, Sch Engn, Newcastle Upon Tyne NE1 7RU, England

[3] Univ Piemonte Orientale, Dept Hlth Sci, I-28100 Novara, Italy

[4] NOVA Srls, Via Am Canobio 4-6, I-28100 Novara, Italy

来源：

PHARMACEUTICS | 2023年 / 15卷 / 03期

关键词：

hydrolytic degradation modeling; bioactive molecules; tissue engineering; bone scaffold; POLY-L-LACTIDE; IN-VITRO; PLGA;

D O I：

10.3390/pharmaceutics15030815

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This work presents a computational model to study the degradation behavior of polyester-based three-dimensional (3D) functionalized scaffolds for bone regeneration. As a case study, we investigated the behavior of a 3D-printed scaffold presenting a functionalized surface with ICOS-Fc, a bioactive protein able to stimulate bone regeneration and healing, inhibiting osteoclast activity. The aim of the model was to optimize the scaffold design to control its degradation and thus the release of grafted protein over time and space. Two different scenarios were considered: (i) a scaffold without macroporosity presenting a functionalized external surface; and (ii) a scaffold presenting an internal functionalized macroporous architecture with open channels to locally deliver the degradation products.

引用

页数：14

共 33 条

[1]

Abderrahim B, 2016, J POLYM BIOPOLYM PHY, V4, P16, DOI DOI 10.12691/JPBPC-4-1-3

[2] Improved Mathematical Model for the Hydrolytic Degradation of Aliphatic Polyesters [J].