Hereditary medullary thyroid cancer

被引：0
作者：
Fendrich, V. [1 ,2 ]
Zahn, A. [1 ]
机构：
[1] Schon Klin Eilbek, Klin Endokrine Chirurg, Hamburg, Germany
[2] Schon Klin Eilbek, Klin Endokrine Chirurg, Dehnhaide 120, D-22081 Hamburg, Germany
来源：
CHIRURGIE | 2023年 / 94卷 / 05期
关键词：
Genotype-phenotype correlation; MEN2; Calcitonin; RET proto-oncogene; Prophylactic thyroidectomy; SURGICAL-MANAGEMENT; CALCITONIN;
D O I：
10.1007/s00104-023-01824-x
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Parafollicular C cells progress via C cell hyperplasia to medullary thyroid cancer (MTC), which can be present even in the first years of life in multiple endocrine neoplasia (MEN) type 2A and 2B patients. Basal calcitonin and carcinoembryonic antigen (CEA) are useful tumor markers for the diagnosis and monitoring. The prognosis depends on the stage when the disease is diagnosed and there is a good genotype-phenotype correlation with the RET proto-oncogene, which can be used for estimation of the risk. The risk-stratified prophylactic thyroidectomy plays a decisive role in the prognosis of known gene mutation carriers.
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收藏
页码：393 / 399
页数：7
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