Altered brain function in patients with vestibular migraine: a study on resting state functional connectivity

被引：11

作者：

Chen, Zhengwei ^{[1
]}

Rong, Liangqun ^{[1
]}

Xiao, Lijie ^{[1
]}

Wang, Quan ^{[2
]}

Liu, Yueji ^{[1
]}

Lin, Cunxin ^{[1
]}

Wang, Jianing ^{[1
]}

Liu, Haiyan ^{[1
]}

Wei, Xiu-e ^{[1
]}

机构：

[1] Xuzhou Med Univ, Dept Neurol, Affiliated Hosp 2, 32 Meijian Rd, Xuzhou 221006, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Med Imaging Dept, Affiliated Hosp 2, 32 Meijian Rd, Xuzhou 221006, Jiangsu, Peoples R China

来源：

NEURORADIOLOGY | 2023年 / 65卷 / 03期

关键词：

Vestibular migraine; Migraine; Resting-state fMRI; Functional connectivity; Independent component analysis; Functional network connectivity; NETWORK CONNECTIVITY; DEFAULT MODE; ABNORMALITIES; ACTIVATION; DIAGNOSIS; TRACKING; CORTEX;

D O I：

10.1007/s00234-022-03086-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose To characterize the altered brain function in patients with vestibular migraine (VM) using resting-state functional magnetic resonance imaging (fMRI). Methods In this prospective study, fMRI images as well as clinical characteristics and behavioral scales were collected from 40 VM patients and 40 healthy controls (HC). All patients received neurological, neuro-otological, and conventional MRI examinations to exclude peripheral vestibular lesions, focal lesions, and other neurological diseases. Seed-based (bilateral parietal operculum cortex 2, OP2) functional connectivity (FC) and independent component analysis (ICA)-based functional network connectivity (FNC) were performed to investigate the brain functional changes in patients with VM. Additionally, the correlations between the altered FC/FNC and behavioral results were analyzed. Results Compared with HC, patients with VM showed increased FC between the left OP2 and right precuneus and exhibited decreased FC between the left OP2 and left anterior cingulate cortex. We also observed increased FC between the right OP2 and regions of the right middle frontal gyrus and bilateral precuneus, as well as decreased FC between the bilateral OP2. Furthermore, patients with VM showed decreased FNC between visual network (VN) and networks of auditory and default mode, and exhibited increased FNC between VN and executive control network. A correlation analysis found that FC between the left OP2 and right precuneus was positively correlated with scores of dizziness handicap inventory (DHI) in patients with VM. Conclusion The present study demonstrated altered brain function in patients with VM.

引用

页码：579 / 590

页数：12

共 58 条

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