Small molecules targeting protein-protein interactions for cancer therapy

被引：28
|
作者：
Wu, Defa [1 ,2 ,3 ]
Li, Yang [1 ,2 ,3 ]
Zheng, Lang [1 ,2 ,3 ]
Xiao, Huan [1 ,2 ,3 ]
Ouyang, Liang [1 ,2 ,3 ]
Wang, Guan [1 ,2 ,3 ]
Sun, Qiu [1 ,2 ,3 ,4 ]
机构：
[1] Sichuan Univ, West China Hosp, Canc Ctr, Dept Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Innovat Ctr Nursing Res, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Sch Nursing, Chengdu 610041, Peoples R China
[4] Sichuan Univ, West China Hosp, West China Med Publishers, Chengdu 610041, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2023年 / 13卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Protein-protein interactions; Cancer; Small molecules; Structure-activity relationships; STRUCTURE-BASED DESIGN; MICROTUBULE-STABILIZING AGENTS; NF-KAPPA-B; STRUCTURAL BASIS; C-MYC; MDM2; INHIBITOR; BINDING-SITES; CELL-DEATH; IAP PROTEINS; P53; PATHWAY;
D O I：
10.1016/j.apsb.2023.05.035
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Protein-protein interactions (PPIs) are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases. Targeting the interaction between tumour-related proteins with emerging small molecule drugs has become an attractive approach for treatment of human diseases, especially tumours. Encouragingly, selective PPI-based therapeutic agents have been rapidly advancing over the past decade, providing promising perspectives for novel therapies for patients with cancer. In this review we comprehensively clarify the discovery and development of small molecule modulators of PPIs from multiple aspects, focusing on PPIs in disease, drug design and discovery strategies, structure-activity relationships, inherent dilemmas, and future directions.
引用
收藏
页码：4060 / 4088
页数：29
相关论文
共 50 条
  • [41] Targeting the protein-protein interactions of the HIV lifecycle
    Tavassoli, Ali
    CHEMICAL SOCIETY REVIEWS, 2011, 40 (03) : 1337 - 1346
  • [42] Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics
    Cossins, Benjamin P.
    Lawson, Alastair D. G.
    MOLECULES, 2015, 20 (09) : 16435 - 16445
  • [43] Tailoring Peptidomimetics for Targeting Protein-Protein Interactions
    Akram, Omar N.
    DeGraff, David J.
    Sheehan, Jonathan H.
    Tilley, Wayne D.
    Matusik, Robert J.
    Ahn, Jung-Mo
    Raj, Ganesh V.
    MOLECULAR CANCER RESEARCH, 2014, 12 (07) : 967 - 978
  • [44] Targeting Protein-Protein Interactions in the HIF System
    Wilkins, Sarah E.
    Abboud, Martine I.
    Hancock, Rebecca L.
    Schofield, Christopher J.
    CHEMMEDCHEM, 2016, 11 (08) : 773 - 786
  • [45] Targeting protein-protein interactions: the HIV protease
    Ganesan, A
    DRUG DISCOVERY TODAY, 1999, 4 (08) : 387 - 388
  • [46] Targeting protein-protein interactions as an anticancer strategy
    Ivanov, Andrei A.
    Khuri, Fadlo R.
    Fu, Haian
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2013, 34 (07) : 393 - 400
  • [47] Targeting Protein-Protein Interactions for Parasite Control
    Taylor, Christina M.
    Fischer, Kerstin
    Abubucker, Sahar
    Wang, Zhengyuan
    Martin, John
    Jiang, Daojun
    Magliano, Marc
    Rosso, Marie-Noelle
    Li, Ben-Wen
    Fischer, Peter U.
    Mitreva, Makedonka
    PLOS ONE, 2011, 6 (04):
  • [48] Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy
    Mori, Mattia
    Manetti, Fabrizio
    Botta, Maurizio
    CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (33) : 3713 - 3728
  • [49] Small molecule inhibitors of protein-protein interactions: Targeting Bcl-2 family proteins to treat cancer
    Elmore, Steven W.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [50] Targeting protein-protein interactions in the DNA damage response pathways for cancer chemotherapy
    McPherson, Kerry Silva
    Korzhnev, Dmitry M.
    RSC CHEMICAL BIOLOGY, 2021, 2 (04): : 1167 - 1195
12345