A case of junctional epidermolysis bullosa intermediate with collagen XVII deficiency treated with dupilumab

被引：1
|
作者：
Zhang, Li [1 ]
Wang, Shangshang [1 ]
Chen, Qinyi [1 ]
Xiang, Leihong [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Dermatol, 12 Wulumuqi Zhong Rd, Shanghai 200040, Peoples R China
来源：
JOURNAL OF DERMATOLOGICAL TREATMENT | 2023年 / 34卷 / 01期
关键词：
Junctional epidermolysis bullosa(1); dupilumab(2); treatment(3); itch(5); pruritus(6); PRURIGINOSA; MUTATIONS;
D O I：
10.1080/09546634.2023.2253943
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Inherited epidermolysis bullosa is a heterogeneous group of hereditary skin diseases characterized by skin (mucosa) fragility, which leads to blistering. Junctional epidermolysis bullosa is associated with mutations in genes expressing proteins of the dermo-epidermal junction. Dupilumab, an antibody that directly targets interleukin (IL)-4 receptor alpha, may be an effective treatment for dystrophic epidermolysis bullosa. We describe a case of junctional epidermolysis bullosa that improved with dupilumab.
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