Mitochondrial homeostasis: a potential target for delaying renal aging

被引：7
作者：
Yang, Ming [1 ,2 ]
Liu, Chongbin [1 ,2 ]
Jiang, Na [1 ,2 ]
Liu, Yan [1 ,2 ]
Luo, Shilu [1 ,2 ]
Li, Chenrui [1 ,2 ]
Zhao, Hao [1 ,2 ]
Han, Yachun [1 ,2 ]
Chen, Wei [1 ,2 ]
Li, Li [1 ,2 ]
Xiao, Li [1 ,2 ]
Sun, Lin [1 ,2 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China
[2] Hunan Key Lab Kidney Dis & Blood Purificat, Changsha, Hunan, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
关键词：
renal aging; mitochondria; mitophagy; oxidative stress; inflammation; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; TUMOR-SUPPRESSOR; LIFE-SPAN; INFLAMMATION; AUTOPHAGY; AGE; KIDNEY; MECHANISMS; SENESCENCE;
D O I：
10.3389/fphar.2023.1191517
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mitochondria, which are the energy factories of the cell, participate in many life activities, and the kidney is a high metabolic organ that contains abundant mitochondria. Renal aging is a degenerative process associated with the accumulation of harmful processes. Increasing attention has been given to the role of abnormal mitochondrial homeostasis in renal aging. However, the role of mitochondrial homeostasis in renal aging has not been reviewed in detail. Here, we summarize the current biochemical markers associated with aging and review the changes in renal structure and function during aging. Moreover, we also review in detail the role of mitochondrial homeostasis abnormalities, including mitochondrial function, mitophagy and mitochondria-mediated oxidative stress and inflammation, in renal aging. Finally, we describe some of the current antiaging compounds that target mitochondria and note that maintaining mitochondrial homeostasis is a potential strategy against renal aging.
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页数：9
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