Mitochondrial homeostasis: a potential target for delaying renal aging

被引：7

作者：

Yang, Ming ^{[1
,2
]}

Liu, Chongbin ^{[1
,2
]}

Jiang, Na ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Luo, Shilu ^{[1
,2
]}

Li, Chenrui ^{[1
,2
]}

Zhao, Hao ^{[1
,2
]}

Han, Yachun ^{[1
,2
]}

Chen, Wei ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Xiao, Li ^{[1
,2
]}

Sun, Lin ^{[1
,2
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China

[2] Hunan Key Lab Kidney Dis & Blood Purificat, Changsha, Hunan, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷

关键词：

renal aging; mitochondria; mitophagy; oxidative stress; inflammation; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; TUMOR-SUPPRESSOR; LIFE-SPAN; INFLAMMATION; AUTOPHAGY; AGE; KIDNEY; MECHANISMS; SENESCENCE;

D O I：

10.3389/fphar.2023.1191517

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondria, which are the energy factories of the cell, participate in many life activities, and the kidney is a high metabolic organ that contains abundant mitochondria. Renal aging is a degenerative process associated with the accumulation of harmful processes. Increasing attention has been given to the role of abnormal mitochondrial homeostasis in renal aging. However, the role of mitochondrial homeostasis in renal aging has not been reviewed in detail. Here, we summarize the current biochemical markers associated with aging and review the changes in renal structure and function during aging. Moreover, we also review in detail the role of mitochondrial homeostasis abnormalities, including mitochondrial function, mitophagy and mitochondria-mediated oxidative stress and inflammation, in renal aging. Finally, we describe some of the current antiaging compounds that target mitochondria and note that maintaining mitochondrial homeostasis is a potential strategy against renal aging.

引用

页数：9

共 125 条

[1] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[2] Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury [J].

Andrianova, Nadezda, V ;

Jankauskas, Stanislovas S. ;

Zorova, Ljubava D. ;

Pevzner, Irina B. ;

Popkov, Vasily A. ;

Silachev, Denis N. ;

Plotnikov, Egor Y. ;

Zorov, Dmitry B. .

CELLS, 2018, 7 (10)

[3] Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats [J].

Annunziata, Giuseppe ;

Jimenez-Garcia, Manuel ;

Tejada, Silvia ;

Moranta, David ;

Arnone, Angela ;

Ciampaglia, Roberto ;

Tenore, Gian Carlo ;

Sureda, Antoni ;

Novellino, Ettore ;

Capo, Xavier .

NUTRIENTS, 2020, 12 (05)

[4] The pathways of mitophagy for quality control and clearance of mitochondria [J].

Ashrafi, G. ;

Schwarz, T. L. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (01) :31-42

[5] Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence [J].

Bae, Eunjin ;

Kim, Jin Hyun ;

Jung, Myeong Hee ;

Jang, Si Jung ;

Lee, Tae Won ;

Jung, Sehyun ;

Lee, Seunghye ;

Jang, Ha Nee ;

Chang, Se-Ho ;

Park, Dong Jun .

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020

[6] Ursolic acid regulates aging process through enhancing of metabolic sensor proteins level [J].

Bahrami, Soroush Alaghehband ;

Bakhtiari, Nuredin .

BIOMEDICINE & PHARMACOTHERAPY, 2016, 82 :8-14

[7] miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes [J].

Bai, Xue-Yuan ;

Ma, Yuxiang ;

Ding, Rui ;

Fu, Bo ;

Shi, Suozhu ;

Chen, Xiang-Mei .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (07) :1252-1261

[8] Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].

Baker, Darren J. ;

Wijshake, Tobias ;

Tchkonia, Tamar ;

LeBrasseur, Nathan K. ;

Childs, Bennett G. ;

van de Sluis, Bart ;

Kirkland, James L. ;

van Deursen, Jan M. .

NATURE, 2011, 479 (7372) :232-U112

[9] Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation [J].

Bharath, Leena P. ;

Agrawal, Madhur ;

McCambridge, Grace ;

Nicholas, Dequina A. ;

Hasturk, Hatice ;

Liu, Jing ;

Jiang, Kai ;

Liu, Rui ;

Guo, Zhenheng ;

Deeney, Jude ;

Apovian, Caroline M. ;

Snyder-Cappione, Jennifer ;

Hawk, Gregory S. ;

Fleeman, Rebecca M. ;

Pihl, Riley M. F. ;

Thompson, Katherine ;

Belkina, Anna C. ;

Cui, Licong ;

Proctor, Elizabeth A. ;

Kern, Philip A. ;

Nikolajczyk, Barbara S. .

CELL METABOLISM, 2020, 32 (01) :44-+

[10] Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies [J].

Bhatti, Jasvinder Singh ;

Bhatti, Gurjit Kaur ;

Reddy, P. Hemachandra .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (05) :1066-1077

← 1 2 3 4 5 6 7 8 9 10 →