Design and synthesis of hexahydro pyrene containing unusual α-amino acid derivatives

被引:0
作者
Kotha, Sambasivarao [1 ]
Gaikwad, Vidyasagar [1 ]
Ansari, Saima [1 ]
机构
[1] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India
关键词
Esterification; Reduction; ethyl isocyanoacetate; hydrolysis; N-acylation; amino acid; STEREOSELECTIVE-SYNTHESIS; PEPTIDOMIMETICS; PEPTIDES;
D O I
10.1007/s12039-023-02170-5
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report constrained a-amino acid derivatives containing hexahydro pyrene unit using ethyl isocyanoacetate as a glycine equivalent. The required precursor 1,4,5,8-tetrakis(bromomethyl)naphthalene 3 was prepared from commercially available naphthalene-1,4,5,8-tetracarboxylic anhydride 4 in a three-step sequence.
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页数:6
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