Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126

被引：12

作者：

Hao, You-Jia ^{[1
,2
]}

Zou, Zheng-Biao ^{[2
]}

Xie, Ming-Min ^{[2
]}

Zhang, Yong ^{[2
]}

Xu, Lin ^{[2
]}

Yu, Hao-Yu ^{[2
]}

Ma, Hua-Bin ^{[3
]}

Yang, Xian-Wen ^{[2
]}

机构：

[1] Shanghai Ocean Univ, Coll Marine Sci, 999 Hucheng Ring Rd, Shanghai 201306, Peoples R China

[2] Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Genet Resources, 184 Daxue Rd, Xiamen 361005, Peoples R China

[3] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Peoples R China

来源：

MARINE DRUGS | 2023年 / 21卷 / 04期

基金：

中国国家自然科学基金;

关键词：

deep sea; fungus; Penicillium sp; cytotoxicity; necroptosis; ASPERGILLUS-VERSICOLOR; XANTHONE DERIVATIVES; SECONDARY METABOLITES; CYTOTOXIC POLYPHENOLS; ENDOLICHENIC FUNGUS; ENDOPHYTIC FUNGUS; ASSIGNMENTS; LEUKEMIA; SYDOWII;

D O I：

10.3390/md21040234

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new xanthones (1 and 2) were isolated from the deep-sea-derived fungus Penicillium sp. MCCC 3A00126 along with 34 known compounds (3-36). The structures of the new compounds were established by spectroscopic data. The absolute configuration of 1 was validated by comparison of experimental and calculated ECD spectra. All isolated compounds were evaluated for cytotoxicity and ferroptosis inhibitory activities. Compounds 14 and 15 exerted potent cytotoxicity against CCRF-CEM cells, with IC50 values of 5.5 and 3.5 mu M, respectively, whereas 26, 28, 33, and 34 significantly inhibited RSL3-induced ferroptosis, with EC50 values of 11.6, 7.2, 11.8, and 2.2 mu M, respectively.

引用

页数：11

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