Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126

被引：12
作者：
Hao, You-Jia [1 ,2 ]
Zou, Zheng-Biao [2 ]
Xie, Ming-Min [2 ]
Zhang, Yong [2 ]
Xu, Lin [2 ]
Yu, Hao-Yu [2 ]
Ma, Hua-Bin [3 ]
Yang, Xian-Wen [2 ]
机构：
[1] Shanghai Ocean Univ, Coll Marine Sci, 999 Hucheng Ring Rd, Shanghai 201306, Peoples R China
[2] Minist Nat Resources, Inst Oceanog 3, Key Lab Marine Genet Resources, 184 Daxue Rd, Xiamen 361005, Peoples R China
[3] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Peoples R China
来源：
MARINE DRUGS | 2023年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
deep sea; fungus; Penicillium sp; cytotoxicity; necroptosis; ASPERGILLUS-VERSICOLOR; XANTHONE DERIVATIVES; SECONDARY METABOLITES; CYTOTOXIC POLYPHENOLS; ENDOLICHENIC FUNGUS; ENDOPHYTIC FUNGUS; ASSIGNMENTS; LEUKEMIA; SYDOWII;
D O I：
10.3390/md21040234
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new xanthones (1 and 2) were isolated from the deep-sea-derived fungus Penicillium sp. MCCC 3A00126 along with 34 known compounds (3-36). The structures of the new compounds were established by spectroscopic data. The absolute configuration of 1 was validated by comparison of experimental and calculated ECD spectra. All isolated compounds were evaluated for cytotoxicity and ferroptosis inhibitory activities. Compounds 14 and 15 exerted potent cytotoxicity against CCRF-CEM cells, with IC50 values of 5.5 and 3.5 mu M, respectively, whereas 26, 28, 33, and 34 significantly inhibited RSL3-induced ferroptosis, with EC50 values of 11.6, 7.2, 11.8, and 2.2 mu M, respectively.
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页数：11
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