Polymer-Based MEMS Sensor for Label-Free Chikungunya Virus Detection

被引:3
作者
Niranjan, Arpana [1 ]
Gupta, Pallavi [1 ]
Rajoria, Manisha [1 ]
机构
[1] Sharda Univ, Sch Engn, Dept Elect & Commun Engn, Greater Noida, Uttar Pradesh, India
关键词
biological applications of polymers; COMSOL multiphysics; diagnosis of chikungunya; piezoelectric MEMS cantilever; sensor;
D O I
10.1002/masy.202200104
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Piezoelectric MEMS (Micro-Electro-Mechanical Systems) Cantilevers have successfully been used in a wide variety of applications in recent years. This paper is a simulation-based study on Micro-cantilever based Piezoelectric MEMS biosensors for Chikungunya Virus (CHIKV) detection. In addition to providing early detection, the proposed method is label-free, faster, and more reliable. The proposed biosensor detects CHIKV E2 protein via MEMS Sensor. The basic principle involves using piezoelectric material on a micro-cantilever for biomaterial detection. A piezoelectric MEMS cantilever is simulated in COMSOL Multiphysics and compared for voltage, stress, and displacement for three materials (silicon, gold, and PDMS). Analytical equations are derived. Post-processing for biosensor design is done in SIMULINK. Simulated voltage, stress, and displacement show a linear relationship with the viral load. PDMS also provided the highest voltage and displacement among the three materials used for MEMS simulation. The graphs show the comparison between simulated and analytical values. Simulation results are also compared to clinical results to prove the biosensor's validity. MEMS Biosensor performance matches with the RT-PCR results, with the added advantage of faster results. Diagnostic tests in the medical field can be performed using the proposed biosensor.
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页数:9
相关论文
共 41 条
[31]  
Sai Mounik P., 2017, IND INST MET SER, V115, P523
[32]  
Shih W. Y., 2008, PIEZOELECTRIC CANTIL, V7
[33]   Development and Validation of a Quantitative, One-Step, Multiplex, Real-Time Reverse Transcriptase PCR Assay for Detection of Dengue and Chikungunya Viruses [J].
Simmons, Monika ;
Myers, Todd ;
Guevara, Carolina ;
Jungkind, Donald ;
Williams, Maya ;
Houng, Huo-Shu .
JOURNAL OF CLINICAL MICROBIOLOGY, 2016, 54 (07) :1766-1773
[34]   Microelectromechanical Systems in Medicine [J].
Sonetha, Vaibhavi ;
Agarwal, Poorvi ;
Doshi, Smeet ;
Kumar, Ridhima ;
Mehta, Bhavya .
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 2017, 37 (04) :580-601
[35]   Molecular and Virological Investigation of a Focal Chikungunya Outbreak in Northern India [J].
Soni, Manisha ;
Singh, Anil Kumar ;
Sharma, Shashi ;
Agarwal, Ankita ;
Gopalan, Natarajan ;
Rao, P. V. Lakshmana ;
Parida, Manmohan ;
Dash, Paban Kumar .
SCIENTIFIC WORLD JOURNAL, 2013,
[36]  
Souza A., 2019, INT SYMP EMP SOFTWAR, V4, P9
[37]   Promising application of monoclonal antibody against chikungunya virus E1-antigen across genotypes in immunochromatographic rapid diagnostic tests [J].
Suzuki, Keita ;
Huits, Ralph ;
Phadungsombat, Juthamas ;
Tuekprakhon, Aekkachai ;
Nakayama, Emi E. ;
van den Berg, Riemsdijk ;
Barbe, Barbara ;
Cnops, Lieselotte ;
Rahim, Rummana ;
Hasan, Abu ;
Iwamoto, Hisahiko ;
Leaungwutiwong, Pornsawan ;
van Esbroeck, Marjan ;
Rahman, Mizanur ;
Shioda, Tatsuo .
VIROLOGY JOURNAL, 2020, 17 (01)
[38]   Anti-Chikungunya Virus Monoclonal Antibody That Inhibits Viral Fusion and Release [J].
Tumkosit, Uranan ;
Siripanyaphinyo, Uamporn ;
Takeda, Naokazu ;
Tsuji, Motonori ;
Maeda, Yusuke ;
Ruchusatsawat, Kriangsak ;
Shioda, Tatsuo ;
Mizushima, Hiroto ;
Chetanachan, Prukswan ;
Wongjaroen, Pattara ;
Matsuura, Yoshiharu ;
Tatsumi, Masashi ;
Tanaka, Atsushi .
JOURNAL OF VIROLOGY, 2020, 94 (19)
[39]   Wearable multifunctional piezoelectric MEMS device for motion monitoring, health warning, and earphone [J].
Wang, Qi ;
Ruan, Tao ;
Xu, Qingda ;
Yang, Bin ;
Liu, Jingquan .
NANO ENERGY, 2021, 89
[40]  
Yarraguntla N, 2018, PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON COMPUTING METHODOLOGIES AND COMMUNICATION (ICCMC 2018), P405, DOI 10.1109/ICCMC.2018.8487679