Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition

被引：10
作者：
Zhou, Mengzhen [1 ,2 ]
Tang, Shi [3 ]
机构：
[1] Shandong First Med Univ, Dept Neurol, Affiliated Hosp 1, Jinan, Shandong, Peoples R China
[2] Shandong Prov Qianfoshan Hosp, Jinan, Shandong, Peoples R China
[3] Shandong First Med Univ, Dept Neurol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China
来源：
FRONTIERS IN MEDICINE | 2023年 / 9卷
关键词：
Alzheimer's disease; cognition; insomnia; orexin; treatment; HYPOCRETIN/OREXIN; INSOMNIA; IMPAIRMENT; SUVOREXANT; SYSTEM; MEMORY; DISRUPTION; PLASTICITY; INSIGHTS; NEURONS;
D O I：
10.3389/fmed.2022.984227
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA.
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页数：7
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