Mixed-ligand copper(II) hydrazone complexes: Synthesis, structure, and anti-lung cancer properties

被引：8
|
作者：
Wu, YouRu [1 ]
Hou, LiXia [1 ]
Lan, JianFeng [2 ]
Yang, Feng [3 ]
Huang, GuoJin [1 ]
Liu, Wei [4 ]
Gou, Yi [1 ]
机构：
[1] Guilin Med Univ, Lab Resp Dis, Affiliated Hosp, Guilin, Guangxi, Peoples R China
[2] Guilin Med Univ, Guangxi Key Lab Mol Med Liver Injury & Repair, Affiliated Hosp, Guilin, Guangxi, Peoples R China
[3] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Guilin, Guangxi, Peoples R China
[4] Nantong Univ, Sch Pharm, Nantong, Jiangsu, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1279卷
关键词：
Copper(II) complexes; Mixed-ligand; Schiff base; Anti-lung cancer activity; SCHIFF-BASE COMPLEXES; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; CRYSTAL-STRUCTURE; APOPTOSIS; THERAPY; CELLS; METAL;
D O I：
10.1016/j.molstruc.2023.134986
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Here we synthesized five mixed-ligand copper(II) Schiff-base complexes, including [Cu(HL1)(pyridine) NO3] 1, [Cu(HL2)(pyridine)Cl] 2, [Cu(HL3)(pyridine)Br] 3, [Cu(HL4)(pyridine)Br] 4, and [Cu(L5)(pyridine)] 5, and performed a series of assays to investigate their anti-lung cancer activities in vitro. The structures of these copper(II) complexes were confirmed by X-ray crystallography and elemental analysis. MTT assay showed that complex 4 exhibited stronger cytotoxicity than other complexes. The wound healing assay showed that complex 4 had the well potential to display anti-metastatic activity. Flow cytometry and fluorescence imaging analysis showed that complex 4 led to cell cycle arrest at the S phase and induced mitochondria-mediated apoptotic. Furthermore, in the 3D A549 spherical model, complex 4 clearly exerts an inhibitory effect.(c) 2023 Elsevier B.V. All rights reserved.
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页数：9
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