The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia

被引：3

作者：

Abolhasani, Shiva ^{[1
,2
]}

Hejazian, Seyyed Sina ^{[1
]}

Karpisheh, Vahid ^{[1
]}

Khodakarami, Atefeh ^{[1
]}

Mohammadi, Hamed ^{[3
]}

Navashenaq, Jamshid Gholizadeh ^{[4
]}

Hojjat-Farsangi, Mohammad ^{[5
,6
]}

Jadidi-Niaragh, Farhad ^{[1
,7
,8
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[3] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[4] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran

[5] Karolinska Inst, Dept Oncol Pathol, Bioclinicum, Stockholm, Sweden

[6] Bushehr Univ Med Sci, Persian Gulf Marine Biotechnol Med Res Ctr, Bushehr, Iran

[7] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran

[8] Tabriz Univ Med Sci, Res Ctr Integrat Med Aging, Aging Res Inst, Tabriz, Iran

来源：

IUBMB LIFE | 2023年 / 75卷 / 03期

关键词：

leukemia; NOTCH1; targeted therapy; therapeutic resistance; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; SECRETASE INHIBITOR PF-03084014; SPLICING FACTOR SF3B1; KAPPA-B ACTIVITY; GAMMA-SECRETASE; T-ALL; RECURRENT MUTATIONS; C-MYC;

D O I：

10.1002/iub.2660

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in different ways like mediating therapeutic resistance; therefore, studying these gene/pathways is essential. This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment.

引用

页码：257 / 278

页数：22

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