Synthesis of Novel Indolylbenzothiazepines/ Indolylbenzoxaziepines Substituted 2-Oxo/Thiobarbituric acids as Potential Anticonvulsant Agents

4-(2'-Oxo/thiobarbiturinyl acid)-2-(2"-halo-1"H-indolyl)-2,3-dihydro--1,5-benzothiazepines (7-10) and 4-(2'-oxo/thiobarbiturinyl acid)-2-(2"-halo-1"H-indolyl)-2,3-dihydro--1,5-benzoxazepines (11-14) undergoes Mannich reaction to afford compounds 4-(2'-oxo/thiobarbiturinyl acid)-2-(2"halo-1"H-indolyl)-3-(substitutedphenyl aminomethylene)-2,3-dihydro-1,5-benzothiazepines (15-22) and 4-(2'-oxo/thiobarbiturinyl acid)-2-(2"-halo-1"H-indolyl)-3-( substitutedphenyl aminomethylene)2,3-dihydro-1,5-benzoxazepines (23-30) correspondingly. All the chemical framework of these newer drugs were elucidated by using elemental and IR and NMR spectroscopy. All these newly synthesized compounds were tested for antiepileptic effect against SMES experimental models and the results were collated with phenytoin sodium-standard drug. Results of antiepileptic profile showed promising effect in most of the derivatives synthesized. Activity equal to standard drug was shown by compounds 9 and 28. The most promising and active compound of this project was found to be 4-(2'- thiobarbiturinyl acid)-2-(2"-chloro-1"H-indolyl)-3-(chlorophenyl aminomethylene)-2,3-dihydro1,5-benzothiazepines, which elicited activity greater than the standard drug. All the antiepileptic drugs of the produced in this projects were also tested for ALD50.