Diversity recovery and probiotic shift of gastric microbiota in functional dyspepsia patients after Helicobacter pylori eradication therapy

被引：2

作者：

Wang, Wenxue ^{[1
,2
]}

Liu, Zhongjian ^{[3
]}

Zhang, Yu ^{[4
]}

Guo, Zhiping ^{[5
]}

Liu, Jieyu ^{[5
]}

Li, Siyun ^{[5
]}

Huang, Jihua ^{[5
]}

Geng, Jiawei ^{[1
,2
,6
]}

Zhang, Fang ^{[5
]}

Guo, Qiang ^{[4
]}

机构：

[1] Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, Dept Infect Dis & Hepat Dis, Kunming, Yunnan, Peoples R China

[2] Kunming Univ Sci & Technol, Sch Med, Kunming, Yunnan, Peoples R China

[3] Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, Inst Basic & Clin Med, Kunming, Yunnan, Peoples R China

[4] Kunming Univ Sci & Technol, Peoples Hosp Yunnan Prov 1, Affiliated Hosp, Dept Gastroenterol, Kunming, Yunnan, Peoples R China

[5] Third Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming, Yunnan, Peoples R China

[6] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金;

关键词：

functional dyspepsia; gastric microbe; microbial diversity; Helicobacter pylori; eradication therapy; SEQUENCES;

D O I：

10.3389/fmicb.2023.1288920

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of Helicobacter pylori eradication on gastric mucosa-colonizing microbes in patients with functional dyspepsia (FD) remain unclear. Here, we explored microbial variation induced by H. pylori infection and eradication treatment in FD patients. Gastric microbial abundance and diversity were significantly reduced in the H. pylori-infected FD patients. Eradication treatment increased alpha and beta diversity of gastric mucosa-colonizing microbes, and promoted the expansion of several probiotic microbes, such as Leuconostoc mesenteroides, which exhibited a matched antagonistic performance against H. pylori. Significant variation was observed in gastric mucosa-colonizing microbes between H. pylori-positive and H. pylori-negative FD patients. Eradication treatment induced microbial diversity recovery and may provide sufficient nutrition and space for probiotic microbes, such as Leuconostoc mesenteroides.

引用

页数：8

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