Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?

被引：20

作者：

Rychter, Anna Maria ^{[1
]}

Lykowska-Szuber, Liliana ^{[1
]}

Zawada, Agnieszka ^{[1
]}

Szymczak-Tomczak, Aleksandra ^{[1
]}

Ratajczak, Alicja Ewa ^{[1
,2
]}

Skoracka, Kinga ^{[1
,2
]}

Kolan, Michalina ^{[3
]}

Dobrowolska, Agnieszka ^{[1
]}

Krela-Kazmierczak, Iwona ^{[1
]}

机构：

[1] Poznan Univ Med Sci, Dept Gastroenterol Dietet & Internal Dis, Przybyszewskiego 49, PL-60355 Poznan, Poland

[2] Poznan Univ Med Sci, Doctoral Sch, Bukowska 70, PL-60812 Poznan, Poland

[3] Nicolaus Copernicus Univ, Fac Med Ludw Rydygier, Coll Med, PL-85094 Bydgoszcz, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 07期

关键词：

obesity; inflammation; colorectal cancer; diet; gut microbiota; HUMAN GUT MICROBIOME; COLON-CANCER; PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; DIETARY PATTERNS; BODY-WEIGHT; IN-VITRO; RISK; INSULIN; GROWTH;

D O I：

10.3390/jcm12072451

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a complex and multifactorial problem of global importance. Additionally, obesity causes chronic inflammation, upregulates cell growth, disturbs the immune system, and causes genomic instability, increasing the risk of carcinogenesis. Colorectal cancer is one of the most common cancers, and it has become a global problem. In 2018, there were around 1.8 million new cases and around 881,000 deaths worldwide. Another risk factor of colorectal cancer associated with obesity is poor diet. A Western diet, including a high intake of red and processed meat and a low consumption of whole grains, fruits, vegetables, and fiber, may increase the risk of both colorectal cancer and obesity. Moreover, the Western diet is associated with a proinflammatory profile diet, which may also affect chronic low-grade inflammation. In fact, people with obesity often present gut dysbiosis, increased inflammation, and risk of colorectal cancer. In this article, the association between obesity and colorectal cancer is discussed, including the most important mechanisms, such as low-grade chronic inflammation, gut dysbiosis, and poor diet.

引用

页数：20

共 152 条

[21]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[22] Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer [J].