Simultaneous dual-modal photoacoustic and harmonic ultrasound microscopy with an optimized acoustic combiner

被引：3

作者：

Zhu, Jingyi ^{[1
]}

Chen, Jiangbo ^{[1
]}

Amjadian, Mohammadreza ^{[1
,2
]}

Liang, Siyi ^{[1
]}

Qu, Zheng ^{[1
]}

Wang, Yue ^{[1
]}

Zhang, Yachao ^{[1
]}

Wang, Lidai ^{[1
,3
]}

机构：

[1] City Univ Hong Kong, Dept Biomed Engn, 83 Tat Chee Ave, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Clear Water Bay, Hong Kong, Peoples R China

[3] City Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China

来源：

BIOMEDICAL OPTICS EXPRESS | 2023年 / 14卷 / 04期

基金：

中国国家自然科学基金;

关键词：

LASER;

D O I：

10.1364/BOE.484038

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Simultaneous photoacoustic (PA) and ultrasound (US) imaging provides rich optical and acoustic contrasts with high sensitivity, specificity, and resolution, making it a promising tool for diagnosing and assessing various diseases. However, the resolution and penetration depth tend to be contradictory due to the increased attenuation of high-frequency ultrasound. To address this issue, we present simultaneous dual-modal PA/US microscopy with an optimized acoustic combiner that can maintain high resolution while improving the penetration of ultrasound imaging. A low-frequency ultrasound transducer is used for acoustic transmission, and a high-frequency transducer is used for PA and US detection. An acoustic beam combiner is utilized to merge the transmitting and receiving acoustic beams with a predetermined ratio. By combining the two different transducers, harmonic US imaging and high-frequency photoacoustic microscopy are implemented. In vivo experiments on the mouse brain demonstrate the simultaneous PA and US imaging ability. The harmonic US imaging of the mouse eye reveals finer iris and lens boundary structures than conventional US imaging, providing a high-resolution anatomical reference for co-registered PA imaging. (c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

引用

页码：1626 / 1635

页数：10