Therapeutic potential of naringin in improving the survival rate of skin flap: A review

被引：6
作者：
Wang, Yincang [1 ]
Li, Xiaodong [2 ]
Lv, Hang [2 ]
Sun, Lin [1 ]
Liu, Bo [1 ]
Zhang, Xiaofeng [3 ]
Xu, Xilin [2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Harbin, Peoples R China
[2] Heilongjiang Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped & Traumatol 3, Harbin, Peoples R China
[3] Heilongjiang Univ Chinese Med, Teaching & Res Sect Orthoped & Traumatol, Harbin, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
关键词：
naringin; skin flap survival; angiogenesis; inflammation; VEGF; ENDOTHELIAL GROWTH-FACTOR; CITRUS FLAVONOIDS; ISCHEMIA/REPERFUSION INJURY; PHARMACOKINETICS; NANOPARTICLES; MECHANISMS; VEGF;
D O I：
10.3389/fphar.2023.1128147
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Naringin is the main component of Drynaria. Modern pharmacological studies have shown that naringin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-apoptotic, anti-ulcer, and anti-osteoporosis effects. Its therapeutic effects have been observed in various clinical models, such as atherosclerosis, cardiovascular diseases, diabetes, neurodegenerative diseases, and rheumatic diseases. This review investigates the pharmacological effects of naringin and the associated mechanisms in improving flap survival. This review will also provide a reference for future rational application of naringin, especially in research to improve flap survival.
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页数：8
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