RUNX3 in Stem Cell and Cancer Biology

被引：15

作者：

Chuang, Linda Shyue Huey ^{[1
]}

Matsuo, Junichi ^{[1
]}

Douchi, Daisuke ^{[2
]}

Mawan, Nur Astiana Bte ^{[1
]}

Ito, Yoshiaki ^{[1
]}

机构：

[1] Natl Univ Singapore, Canc Sci Inst Singapore, NUS Ctr Canc Res, Yong Loo Lin Sch Med, 14 Med Dr 12-01, Singapore 117599, Singapore

[2] Tohoku Univ, Dept Surg, Grad Sch Med, Sendai 9808574, Japan

来源：

CELLS | 2023年 / 12卷 / 03期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

RUNX3; stem cells; cancer; cell cycle; proliferation; differentiation block; early-stage cancer; GASTRIC EPITHELIAL-CELLS; CBF-BETA HOMOLOG; TUMOR-SUPPRESSOR; BREAST-CANCER; DEVELOPMENTAL REGULATORS; AURORA KINASE; EXPRESSION; FAMILY; ROLES; MECHANISMS;

D O I：

10.3390/cells12030408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The runt-related transcription factors (RUNX) play prominent roles in cell cycle progression, differentiation, apoptosis, immunity and epithelial-mesenchymal transition. There are three members in the mammalian RUNX family, each with distinct tissue expression profiles. RUNX genes play unique and redundant roles during development and adult tissue homeostasis. The ability of RUNX proteins to influence signaling pathways, such as Wnt, TGF beta and Hippo-YAP, suggests that they integrate signals from the environment to dictate cell fate decisions. All RUNX genes hold master regulator roles, albeit in different tissues, and all have been implicated in cancer. Paradoxically, RUNX genes exert tumor suppressive and oncogenic functions, depending on tumor type and stage. Unlike RUNX1 and 2, the role of RUNX3 in stem cells is poorly understood. A recent study using cancer-derived RUNX3 mutation R122C revealed a gatekeeper role for RUNX3 in gastric epithelial stem cell homeostasis. The corpora of RUNX3(R122C/R122C) mice showed a dramatic increase in proliferating stem cells as well as inhibition of differentiation. Tellingly, RUNX3(R122C/R122C) mice also exhibited a precancerous phenotype. This review focuses on the impact of RUNX3 dysregulation on (1) stem cell fate and (2) the molecular mechanisms underpinning early carcinogenesis.

引用

页数：13

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