Progress in vaccines against peste des petits ruminants virus

被引:0
作者
Niedbalski, Wieslaw [1 ,2 ]
机构
[1] Natl Vet Res Inst, Dept Foot & Mouth Dis, Wodna 7, PL-98220 Zdunska Wola, Poland
[2] Wodna 7, PL-98220 Zdunska Wola, Poland
来源
MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE | 2023年 / 79卷 / 04期
关键词
peste des petits ruminants; recombinant vaccines; differentiation of infected from vaccinated animals (DIVA); novel DIVA vaccines; PROTECTIVE IMMUNE-RESPONSE; RINDERPEST VIRUS; HEMAGGLUTININ PROTEIN; VARIABLE REGIONS; H-PROTEINS; IMMUNIZATION; ANTIBODY; IMMUNOGENICITY; STRAIN; MEMORY;
D O I
10.21521/mw.6747
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Peste des petits ruminants (PPR) is a highly contagious and economically important viral disease of both domestic (goats and sheep) and wild small ruminants. Due to the devastating effect of this disease on livestock and livelihoods, the Food and Agriculture Organization of the United Nations (FAO) and the World Organization for Animal Health (WOAH) endorsed the Global Strategy for the Control and Eradication of PPR (PPR GCES) and launched the PPR Global Eradication Programme (PPR GEP) to eradicate PPRV by 2030. In order to achieve this goal, a potent, safe and efficacious live-attenuated PPR vaccine with long-lasting immunity is available for immunoprophylaxis. However, the live-attenuated PPR vaccines are thermolabile and require maintenance of an effective cold chain to deliver to the field. In addition, infected animals cannot be differentiated from vaccinated ones (DIVA). To overcome these limitations, some new generation PPR vaccines have been developed: poxvirus vaccine, positive and negative marker vaccine through reverse genetic approach, chimeric vaccine, anti-idiotypic vaccine, subunit vaccine, virus-like particles vaccine, edible vaccine and combined vaccines. Novel recombinant PPR DIVA vaccines were evaluated in goats for safety and efficacy, and all vaccinated animals were clinically protected against an intranasal PPRV challenge. Furthermore, newly developed ELISAs were capable of differentiating between infected and vaccinated animals. Therefore, these DIVA vaccines and the associated tests can facilitate the serological monitoring process and speed up global PPR eradication through vaccination.
引用
收藏
页码:163 / 167
页数:5
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