Preparation and Identification of New 1,4-bis (5,3-substituted- 2,3-dihydro-1H-pyrazole-1-yl) Buta-1,4-Dione Derivatives with Their Antibacterial Effect Evaluation

被引：3

作者：

Beebany, Shakhawan ^{[1
]}

Jasim, Saad Salem ^{[1
]}

Al-Tufah, Mohammad M. ^{[2
]}

Arslan, Sevgi Samih Hidayet ^{[3
]}

机构：

[1] Univ Kirkuk, Coll Sci, Chem Dept, Kirkuk, Iraq

[2] Minist Educ, Directorate Educ, Kirkuk, Iraq

[3] Univ Kirkuk, Coll Dent, Kirkuk, Iraq

来源：

CHEMICAL METHODOLOGIES | 2023年 / 7卷 / 02期

关键词：

Pyrazole; Cyclization; Succinicdihydrazide; Chalcones; Butadione; Antibacterial effect;

D O I：

10.22034/CHEMM.2023.365060.1614

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 5,3-substituted-2,3-dihydro-1H-pyrazole derivatives (P1-10) have been synthesized via a cyclization reaction of substituted chalcones with succinichydrazide. Structures of the prepared compounds were identified by FT-IR, and some of them were characterized by Nuclear Magnetic Resonance for proton 1H-NMR and Nuclear Magnetic Resonance for carbon 13C-NMR. The heat of formation (HF) and steric energy (SE) have been calculated using (MOPAC) and (MM2) methods, respectively, using (CS-Chemoffice-version 6.0) program. Additionally, the biological activity for final products has been evaluated against gram-positive (staphylococcus aureus and staphylococcus epidermidis) and negative bacteria (escherichia coli and pseudomonas aeruginosa).

引用

页码：123 / 136

页数：14