Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome

被引：3

作者：

Sloan, Elizabeth E. ^{[1
,2
,3
]}

Kmetova, Katarina ^{[4
]}

Naveenkumar, Somanathapura K. ^{[4
]}

Kluge, Lyndsay ^{[4
]}

Chong, Emily ^{[4
]}

Hoy, Claire K. ^{[4
]}

Yalavarthi, Srilakshmi ^{[4
]}

Sarosh, Cyrus ^{[4
]}

Baisch, Jeanine ^{[5
]}

Walters, Lynnette ^{[2
]}

Nassi, Lorien ^{[1
,2
,3
]}

Fuller, Julie ^{[1
,2
,3
]}

Turnier, Jessica L. ^{[6
]}

Pascual, Virginia ^{[5
]}

Wright, Tracey B. ^{[1
,2
,3
]}

Madison, Jacqueline A. ^{[4
,6
]}

Knight, Jason S. ^{[4
]}

Zia, Ayesha ^{[3
,7
]}

Zuo, Yu ^{[4
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Pediat, Div Pediat Rheumatol, Dallas, TX 75390 USA

[2] Scottish Rite Children, Dallas, TX USA

[3] Childrens Med Ctr, Dallas, TX USA

[4] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA

[5] Weill Cornell Med, Gale & Ira Drukier Inst Childrens Hlth, New York, NY USA

[6] Univ Michigan, Div Pediat Rheumatol, Dept Pediat, Ann Arbor, MI USA

[7] Univ Texas Southwestern Med Ctr, Dept Pediat, Div Pediat Hematol Oncol, Dallas, TX USA

来源：

CLINICAL IMMUNOLOGY | 2024年 / 261卷

基金：

新加坡国家研究基金会;

关键词：

Antiphospholipid syndrome; Pediatric; Non -criteria antiphospholipid antibodies; Calprotectin; Thrombocytopenia; NEUTROPHIL EXTRACELLULAR TRAPS; ANTIPHOSPHATIDYLSERINE/PROTHROMBIN ANTIBODIES; DOMAIN I; THROMBOSIS; ASSOCIATION; UPDATE;

D O I：

10.1016/j.clim.2024.109926

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0.008), anti-phosphatidylserine/prothrombin (aPS/PT) IgG (p < 0.001), and aPS/PT IgM (p < 0.001) were significantly associated with venous thrombosis. Positive anti-D1 IgG (p < 0.001), aPS/PT IgG (p < 0.001), and aPS/PT IgM (p = 0.001) were also associated with non-thrombotic manifestations of APS, such as thrombocytopenia. Increased levels of calprotectin were detected in children with APS. Calprotectin correlated positively with absolute neutrophil count (r = 0.63, p = 0.008) and negatively with platelet count (r = -0.59, p = 0.015). Mechanistically, plasma from pediatric APS patients with high calprotectin levels impaired platelet viability in a dose-dependent manner.

引用

页数：6

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