Mathematical Modeling of Micro-/Nanoparticles Transport in Blood Vessels: A Review

被引：1

作者：

Ashrafmansouri, Seyedeh-Saba ^{[1
]}

Nasr Esfahany, Mohsen ^{[2
]}

Ashrafmansouri, Seyedeh-Samira ^{[3
]}

机构：

[1] Univ Larestan, Dept Chem Engn, Lar 7431813115, Iran

[2] Isfahan Univ Technol, Dept Chem Engn, Esfahan 8415683111, Iran

[3] Shiraz Univ, Sch Sci, Dept Biol, Shiraz 7146713565, Iran

来源：

KOREAN JOURNAL OF CHEMICAL ENGINEERING | 2024年 / 41卷 / 05期

关键词：

Transport phenomena; Mathematical modeling; Drug delivery; Nanoparticle; Blood; ABDOMINAL AORTIC-ANEURYSM; TARGETED DRUG-DELIVERY; MAGNETIC NANOPARTICLES; MASS-TRANSFER; SILICA NANOPARTICLES; SUPERPARAMAGNETIC PARTICLES; MARGINATION PROPENSITY; NUMERICAL-SIMULATION; HYBRID NANOFLUID; CONTINUUM MODEL;

D O I：

10.1007/s11814-024-00071-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeted drug delivery using drug-carrying nanoparticles has emerged as a promising approach for the treatment of diseases such as cancer. This review paper provides an overview of the current state of the art in modeling the transport and margination of micro-/nanoparticles in blood vessels. The review examines single-particle models, which consider a single micro-/nanoparticle, and multi-particle models, which consider a large number of particles in the bloodstream. The models are assessed based on factors such as the geometry of the blood vessel, the type, shape, size, and concentration of micro-/nanoparticles, the type of blood flow, the mathematical modeling approach, investigated parameters, and observed results. By analyzing the literature, this review aims to identify the desired properties of micro-/nanopharmaceuticals and to highlight the limiting factors of particle transport in the vascular system. The findings of this review can provide useful insights for researchers working on the development of more effective drug delivery strategies.

引用

页码：1273 / 1305

页数：33

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