A Nef Precursor or Benign Counterpart: High Prevalence of Healthy Subjects with Antibody Reactivity to the C3-Convertase

被引：1
作者：
Culek, Christopher T. [1 ,2 ]
Nester, Carla M. [1 ,2 ,3 ]
机构：
[1] Univ Iowa, Stead Family Childrens Hosp, Iowa City, IA USA
[2] Univ Iowa, Mol Otolaryngol & Renal Res Lab, Iowa City, IA USA
[3] Univ Iowa, Stead Family Childrens Hosp, 285 Newton Rd,5294 CBRB, Iowa City, IA 52242 USA
来源：
KIDNEY360 | 2023年 / 4卷 / 11期
关键词：
CKD; complement; glomerulonephritis; glomerulopathy; immunology; C-3 NEPHRITIC FACTOR; HYPOCOMPLEMENTEMIA; AUTOANTIBODY; CONVERTASE;
D O I：
10.34067/KID.0000000000000260
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Key PointsThere are two anticonvertase antibody populations-Nephritic Factors which cause complement dysregulation and C3CAbs which do not.C3CAbs are highly prevalent in the healthy adult population (>95% prevalence).C3CAbs suggest a direction of study to determine the origin of Nephritic Factors.
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收藏
页码：1615 / 1622
页数：8
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