Cargoes of exosomes function as potential biomarkers for Mycobacterium tuberculosis infection

被引：6
作者：
Wang, Nan [1 ]
Yao, Yongliang [1 ]
Qian, Yingfen [2 ]
Qiu, Dewen [3 ]
Cao, Hui [4 ]
Xiang, Huayuan [1 ]
Wang, Jianjun [1 ]
机构：
[1] Jiangsu Univ, Dept Clin Lab, Kunshan Hosp Affiliated, Suzhou, Jiangsu, Peoples R China
[2] Kunshan Fourth Peoples Hosp, Dept Clin Lab, Suzhou, Jiangsu, Peoples R China
[3] Jiangxi Maternal & Child Hlth Hosp, Maternal Child Heath Hosp, Nanchang Coll, Dept Clin Lab, Nanchang, Peoples R China
[4] Jiangsu Prov CDCP, Dept Food & Nutr Safety, Nanjing, Jiangsu, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
中国国家自然科学基金;
关键词：
exosomes; mycobacterium tuberculosis; biomarkers; diagnosis; tuberculosis; BLOOD MONONUCLEAR-CELLS; EXTRACELLULAR VESICLES; PERIPHERAL-BLOOD; CIRCULAR RNA; DIAGNOSTIC BIOMARKER; PROTEOMIC ANALYSIS; MACROPHAGES; BIOGENESIS; STRATEGIES; PROTEINS;
D O I：
10.3389/fimmu.2023.1254347
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Exosomes as double-membrane vesicles contain various contents of lipids, proteins, mRNAs and non-coding RNAs, and involve in multiple physiological processes, for instance intercellular communication and immunomodulation. Currently, numerous studies found that the components of exosomal proteins, nucleic acids or lipids released from host cells are altered following infection with Mycobacterium tuberculosis. Exosomal contents provide excellent biomarkers for the auxiliary diagnosis, efficacy evaluation, and prognosis of tuberculosis. This study aimed to review the current literatures detailing the functions of exosomes in the procedure of M. tuberculosis infection, and determine the potential values of exosomes as biomarkers to assist in the diagnosis and monitoring of tuberculosis.
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收藏
页数：13
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