A Systematic Review of tACS Effects on Cognitive Functioning in Older Adults Across the Healthy to Dementia Spectrum

被引:3
作者
Kraft, Jacob D. [1 ,2 ]
Hampstead, Benjamin M. [1 ,3 ]
机构
[1] Univ Michigan, Dept Psychiat, Res Program Cognit & Neuromodulat Based Intervent, 4250 Plymouth Rd, Ann Arbor, MI 48105 USA
[2] Ohio State Univ, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA
[3] VA Ann Arbor Healthcare Syst, Mental Hlth Serv, Neuropsychol Sect, Ann Arbor, MI 48105 USA
关键词
tACS; Older adults; Cognitive impairment; Cognitive function; Systematic review; ALTERNATING-CURRENT STIMULATION; TRANSCRANIAL ELECTRICAL-STIMULATION; ALZHEIMERS-DISEASE; MEMORY PERFORMANCE; GAMMA-TACS; IMPAIRMENT; SYNCHRONIZATION; OSCILLATIONS; ALPHA; NEUROMODULATION;
D O I
10.1007/s11065-023-09621-3
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Transcranial alternating current stimulation (tACS) is a form of noninvasive brain stimulation that has experienced rapid growth within the aging population over the past decade due to its potential for modulating cognitive functioning across the "intact" to dementia spectrum. For this reason, we performed a systematic review of the literature to evaluate the efficacy of tACS on cognitive functioning in older adults, including those with cognitive impairment. Our review was completed in June 2023 using Psych INFO, Embase, PubMed, and Cochrane databases. Out of 479 screened articles, 21 met inclusion criteria and were organized according to clinical diagnoses. Seven out of nine studies targeted cognitively intact older adults and showed some type of cognitive improvement after stimulation, whereas nine out of twelve studies targeted clinical diagnoses and showed improved cognitive performance to varying degrees. Studies showed considerable heterogeneity in methodology, stimulation parameters, participant characteristics, choice of cognitive task, and analytic strategy, all of which reinforce the need for standardized reporting of tACS methods. Through this heterogeneity, multiple patterns are described, such as disease progression influencing tACS effects and the need for individualized tailoring. For clinical translation, it is imperative that the field (a) better understand the physiological effects of tACS in these populations, especially in respect to biomarkers, (b) document a causal relationship between tACS delivery and neurophysiological/cognitive effects, and (c) systematically establish dosing parameters (e.g., amplitude, stimulation frequency, number and duration of sessions, need for booster/maintenance sessions).
引用
收藏
页码:1165 / 1190
页数:26
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