Roles of MT-ND1 in Cancer

被引：7
作者：
Xu, Yi-chun [1 ,2 ]
Su, Jun [1 ,2 ]
Zhou, Jia-jing [1 ]
Yuan, Qing [1 ]
Han, Jun-song [1 ,2 ]
机构：
[1] Tongji Univ, Shanghai Tongji Hosp, Dept Pathol, Tongji Hosp, Shanghai 200065, Peoples R China
[2] Shanghai Biochip Ltd Corp, Natl Engn Res Ctr Biochip, Shanghai 201203, Peoples R China
来源：
CURRENT MEDICAL SCIENCE | 2023年 / 43卷 / 05期
基金：
中国国家自然科学基金;
关键词：
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1; cancer; biomarker; mutation; MITOCHONDRIAL-DNA MUTATIONS; HEREDITARY OPTIC NEUROPATHY; RESPIRATORY COMPLEX I; BREAST-CANCER; COPY NUMBER; MICROSATELLITE INSTABILITY; HEPATOCELLULAR-CARCINOMA; SEQUENCE VARIATION; SOMATIC MUTATIONS; 4977BP DELETION;
D O I：
10.1007/s11596-023-2771-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.
引用
收藏
页码：869 / 878
页数：10
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