Roles of MT-ND1 in Cancer

被引：4
|
作者：
Xu, Yi-chun [1 ,2 ]
Su, Jun [1 ,2 ]
Zhou, Jia-jing [1 ]
Yuan, Qing [1 ]
Han, Jun-song [1 ,2 ]
机构：
[1] Tongji Univ, Shanghai Tongji Hosp, Dept Pathol, Tongji Hosp, Shanghai 200065, Peoples R China
[2] Shanghai Biochip Ltd Corp, Natl Engn Res Ctr Biochip, Shanghai 201203, Peoples R China
来源：
CURRENT MEDICAL SCIENCE | 2023年 / 43卷 / 05期
基金：
中国国家自然科学基金;
关键词：
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1; cancer; biomarker; mutation; MITOCHONDRIAL-DNA MUTATIONS; HEREDITARY OPTIC NEUROPATHY; RESPIRATORY COMPLEX I; BREAST-CANCER; COPY NUMBER; MICROSATELLITE INSTABILITY; HEPATOCELLULAR-CARCINOMA; SEQUENCE VARIATION; SOMATIC MUTATIONS; 4977BP DELETION;
D O I：
10.1007/s11596-023-2771-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.
引用
收藏
页码：869 / 878
页数：10
相关论文
共 50 条
  • [1] Roles of MT-ND1 in Cancer
    Yi-chun Xu
    Jun Su
    Jia-jing Zhou
    Qing Yuan
    Jun-song Han
    Current Medical Science, 2023, 43 : 869 - 878
  • [2] Quantitative detection of circulating MT-ND1 as a potential biomarker for colorectal cancer
    Xu, Yichun
    Zhou, Jiajing
    Yuan, Qing
    Su, Jun
    Li, Qian
    Lu, Xiaoliang
    Zhang, Liwen
    Cai, Zhai
    Han, Junsong
    BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2021, 21 (05) : 577 - 586
  • [3] Leber hereditary optic neuropathy and a new MT-ND1 pathologic mutation
    Esteban, O.
    Martinez-Romero, I.
    Herrero-Martin, M. D.
    Llobet, L.
    Emperador, S.
    Martin-Navarro, A.
    Narberhaus, B.
    Ascaso, F. J.
    Lopez-Gallardo, E.
    Montoya, J.
    Ruiz-Pesini, E.
    ACTA OPHTHALMOLOGICA, 2014, 92
  • [4] New MT-ND1 pathologic mutation for Leber hereditary optic neuropathy
    Martinez-Romero, Inigo
    Dolores Herrero-Martin, M.
    Llobet, Laura
    Emperador, Sonia
    Martin-Navarro, Antonio
    Narberhaus, Bernat
    Ascaso, Francisco J.
    Lopez-Gallardo, Ester
    Montoya, Julio
    Ruiz-Pesini, Eduardo
    CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2014, 42 (09): : 856 - 864
  • [5] Genetic diversities of MT-ND1 and MT-ND2 genes are associated with high-altitude adaptation in yak
    Shi, Yu
    Hu, Yongsong
    Wang, Jie
    Elzo, Mauricio A.
    Yang, Xue
    Lai, Songjia
    MITOCHONDRIAL DNA PART A, 2018, 29 (03) : 485 - 494
  • [6] mt-COX1, mt-ND1 and CREBP are indicators of intramuscular fat content in Hanwoo (Korean cattle)
    Lee, Seung Hwan
    Kim, Seung Chang
    Choi, Bong-Hwan
    Lim, Dajeong
    Kim, Nam Kuk
    Lee, Jun Heon
    Kim, Oun Hyun
    Lee, Chang Soo
    Kim, Hyeong Cheol
    Yang, Boh Suk
    Hong, Seong Koo
    LIVESTOCK SCIENCE, 2012, 146 (2-3) : 160 - 167
  • [7] Mitochondrial complex I subunit MT-ND1 mutations affect disease progression
    Lin, Xi
    Zhou, Yanhong
    Xue, Lei
    HELIYON, 2024, 10 (07)
  • [8] 3697G>A in MT-ND1 is a causative mutation in mitochondrial disease
    Spangenberg, Lucia
    Grana, Martin
    Greif, Gonzalo
    Suarez-Rivero, Juan M.
    Krysztal, Karina
    Tapie, Alejandra
    Boidi, Maria
    Fraga, Valeria
    Lemes, Aida
    Guecaimburu, Rosario
    Cerisola, Alfredo
    Sanchez-Alcazar, Jose A.
    Robello, Carlos
    Raggio, Victor
    Naya, Hugo
    MITOCHONDRION, 2016, 28 : 54 - 59
  • [9] Expression of mitochondrial genes MT-ND1, MT-ND6, MT-CYB, MT-COI, MT-ATP6, and 12S/MT-RNR1 in colorectal adenopolyps
    Wallace, LaShanale
    Mehrabi, Sharifeh
    Bacanamwo, Methode
    Yao, Xuebiao
    Aikhionbare, Felix O.
    TUMOR BIOLOGY, 2016, 37 (09) : 12465 - 12475
  • [10] The MT-ND1 and MT-ND5 genes are mutational hotspots for Chinese families with clinical features of LHON but lacking the three primary mutations
    Zou, Yang
    Jia, Xiaoyun
    Zhang, A-Mei
    Wang, Wen-Zhi
    Li, Shiqiang
    Guo, Xiangming
    Kong, Qing-Peng
    Zhang, Qingjiong
    Yao, Yong-Gang
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 399 (02) : 179 - 185
12345