Clinical and patient-reported outcomes from the first 4 years of a Psoriasis Biologics Registry in Singapore

被引：1

作者：

Koh, Xuan Qi ^{[1
]}

Oon, Hazel H. ^{[1
,2
]}

Chong, Wei-Sheng ^{[1
]}

Lee, Bernett ^{[3
]}

Zhao, Xiahong ^{[1
]}

Tan, Eugene S. T. ^{[1
]}

机构：

[1] Natl Skin Ctr, Singapore, Singapore

[2] Skin Res Inst Singapore, Singapore, Singapore

[3] Nanyang Technol Univ, Ctr Biomed Informat, Singapore, Singapore

来源：

EXPERIMENTAL DERMATOLOGY | 2023年 / 32卷 / 11期

关键词：

adalimumab; biologics; psoriasis; registries; ustekinumab; SAFETY;

D O I：

10.1111/exd.14910

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Interim analysis of the National Skin Centre Singapore Psoriasis Biologics Registry (SINGPSOR) from August 2017 to May 2021, in which 58 patients were analysed, showing that those receiving biologic treatment had significantly more severe psoriasis based on PASI (Psoriasis Area and Severity Index), BSA (body surface area) and PGA (Physician Global Assessment) measures at baseline, demonstrated a statistically non-significant trend towards greater improvement with treatment, and had a lower percentage of adverse events compared to those receiving conventional systemic therapy. Future analyses of SINGPSOR, with larger sample size and longer follow-up, will be invaluable to further characterize these patients and their treatment outcomes.

引用

收藏

页码：2023 / 2028

页数：6

相关论文

共 16 条

[1] Review of European registries for psoriasis [J].

Amin, Mina ;

Lee, Erica B. ;

Bhutani, Tina ;

Wu, Jashin J. .

JOURNAL OF DERMATOLOGICAL TREATMENT, 2019, 30 (03) :227-236

[2] Review of US registries for psoriasis [J].

Amin, Mina ;

No, Daniel J. ;

Wu, Jashin J. .

JOURNAL OF DERMATOLOGICAL TREATMENT, 2017, 28 (08) :697-701

[3] Comparison of Biologics and Oral Treatments for Plaque Psoriasis A Meta-analysis [J].

Armstrong, April W. ;

Puig, Luis ;

Joshi, Avani ;

Skup, Martha ;

Williams, David ;

Li, Junlong ;

Betts, Keith A. ;

Augustin, Matthias .

JAMA DERMATOLOGY, 2020, 156 (03) :258-269

[4] How is safety of dermatology drugs assessed: trials, registries, and spontaneous reporting [J].

Asfour, Leila ;

Yiu, Zenas Z. N. ;

Warren, Richard B. .

EXPERT OPINION ON DRUG SAFETY, 2020, 19 (04) :449-457

[5] Clinical experience of adalimumab in the treatment of psoriasis - A 10-year journey in a tertiary dermatology centre [J].

Chan, Wai Man Mandy ;

Oon, Hazel Hweeboon ;

Chong, Wei-Sheng .

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, 2018, 84 (02) :205-208

[6] Efficacy and safety of ustekinumab in the treatment of moderate to severe plaque psoriasis in Singapore [J].

Chan, Wai Sze Agnes ;

Wong, Yisheng ;

Oon, Hazel Hwee Boon ;

Theng, Colin Thiam Seng ;

Chong, Wei-Sheng .

SINGAPORE MEDICAL JOURNAL, 2023, 64 (07) :434-438

[7] Current status and future prospects for biologic treatments of psoriasis [J].

Cline, Abigail ;

Hill, Dane ;

Lewallen, Robin ;

Feldman, Steven R. .

EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2016, 12 (12) :1273-1287

[8] Long-term safety of nine systemic medications for psoriasis: A cohort study using the Spanish Registry of Adverse Events for Biological Therapy in Dermatological Diseases (BIOBADADERM) Registry [J].

Dauden, Esteban ;

Carretero, Gregorio ;

Rivera, Raquel ;

Ferrandiz, Carlos ;

Llamas-Velasco, Mar ;

de la Cueva, Pablo ;

Belinchon, Isabel ;

Jose Gomez-Garcia, Francisco ;

Herrera-Acosta, Enrique ;

Patricia Ruiz-Genao, Diana ;

Ferran-Farres, Marta ;

Alsina, Merce ;

Baniandres-Rodriguez, Ofelia ;

Luis Sanchez-Carazo, Jose ;

Sahuquillo-Torralba, Antonio ;

Rodriguez Fernandez-Freire, Lourdes ;

Vilar-Alejo, Jaime ;

Garcia-Donoso, Carmen ;

Manuel Carrascosa, Jose ;

Herrera-Ceballos, Enrique ;

Luis Lopez-Estebaranz, Jose ;

Botella-Estrada, Rafael ;

Segovia-Munoz, Eva ;

Angel Descalzo, Miguel ;

Garcia-Doval, Ignacio .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2020, 83 (01) :139-150

[9] Treatment modalities and risk of adverse events associated with biologic therapy: A 10-year observational review of the Australasian Psoriasis Registry [J].

Doolan, Brent J. ;

Koye, Digsu ;

Ling, Joanna ;

Cains, Geoffrey D. ;

Baker, Christopher ;

Foley, Peter ;

Dolianitis, Con .

AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2021, 62 (01) :E47-E54

[10] Heterogeneity of Response to Biologic Treatment: Perspective for Psoriasis [J].

Edson-Heredia, Emily ;

Sterling, Kimberly L. ;

Alatorre, Carlos I. ;

Carter, Gebra Cuyun ;

Paczkowski, Rosirene ;

Zarotsky, Victoria ;

Maeda-Chubachi, Tomoko .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 (01) :18-23